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Selinexor treatment or XPO1 siRNA transfection induced the expression of let-7d (A), miR-34c (B) and miR-320 (C), and reduced the expression of miR-205 (D). MiaPaCa-2, AsPC-1 and L3.6pl PDAC cells were treated with 500 nM selinexor or transfected with miR-145 mimic or control mimic for 48 hours. The total RNA from each sample was extracted and subjected to real-time RT-PCR for detection of let-7d, miR-34c, miR-320 and miR-205 expression.
