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. 2017 Jul 31;8(47):82674–82688. doi: 10.18632/oncotarget.19752

Table 5. KEGG pathway analysis of dysregulated genes identified from GE microarray.

KEGG pathways Count P-value Genes up Genes down Fold enrichment
Cell adhesion molecules (CAMs) 10 1.08E-02 OCLN, NLGN4X, CLDN1 HLA-DQB1, NTNG1, CNTN1, ITGB2, ITGA4, CLDN20, HLA-F 2.72
Glycosaminoglycan biosynthesis - heparan sulfate / heparin 4 2.29E-02 XYLT1 HS3ST3A1, HS3ST2, HS3ST3B1 6.43
ECM-receptor interaction 7 2.43E-02 COL5A1 LAMA1, COL4A2, COL1A2, COL6A1, ITGA4, FN1 3.11
Pathways in cancer 18 2.43E-02 FZD10, FGFR3, MMP9, FGF2 LAMA1, FOS, PTGER1, COL4A2, RAC2, RAC3, RASGRP2, EGLN3, FGF13, HHIP, FZD2, GLI2, MMP1, FN1 1.77
Regulation of actin cytoskeleton 11 4.55E-02 FGFR3, SCIN, FGF2 CHRM4, RAC2, RAC3, FGF13, ITGB2, ITGA4, MYLK, FN1 2.01
Focal adhesion 10 8.41E-02 COL5A1 LAMA1, COL4A2, RAC2, RAC3, COL1A2, COL6A1, ITGA4, MYLK, FN1 1.87
MAPK signaling pathway 10 2.11E-01 FGFR3, FGF2, CACNA1A MEF2C, FOS, RAC2, RAC3, RASGRP2, DUSP10, FGF13 1.51
cGMP-PKG signaling pathway 7 2.56E-01 RGS2 MEF2C, KCNMB4, ATP1A4, ATP1A1, ADRA2C, MYLK 1.63
Transcriptional misregulation in cancer 7 2.65E-01 LMO2, UTY, MMP9 MEF2C, FLI1, NGFR, MMP3 1.61
PI3K-Akt signaling pathway 12 2.75E-01 FGFR3, FGF2, COL5A1 LAMA1, COL4A2, COL1A2, COL6A1, FGF13, TLR4, NGFR, ITGA4, FN1 1.34
Oxytocin signaling pathway 6 3.85E-01 RGS2 MEF2C, FOS, KCNJ12, KCNJ2, MYLK 1.47
cAMP signaling pathway 7 4.01E-01 FOS, RAC2, RAC3, ATP1A4, ATP1A1, HHIP, HTR1F 1.36
Adherens junction 3 5.50E-01 PTPRB, RAC2, RAC3 1.63
Tight junction 4 6.91E-01 EPB41L3, OCLN, CLDN1 CLDN20 1.13