Figure 10.

This diagram exemplifies the features evaluated by each modality. Considering a network of cortical structures (A), if one of the cortical regions is lesioned after a stroke, its connections are also affected (B; shaded gray node and gray lines). If all connections had a similar importance toward behavior (aphasia), CLSM would not distinguish between them. However, CLSM can identify which connections are more important (C; blue line). As such, CLSM is a subset of cortical lesion mapping. CDLSM, in turn, provides information about the direct and indirect connections that may be crucial for behavior (D; blue lines).