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. 2017 Jul 7;8(50):87107–87123. doi: 10.18632/oncotarget.19081

Figure 6. Inhibiting ERK1/2 activation by PD98059 prevents propoxur-induced MMP-2 overexpression, and cell migration and invasion.

Figure 6

Both MCF-7 and MDA-MB-231 cells were cultured without or with 100 μM propoxur, or 100 μM propoxur + 100 μM PD98059. (A) Representative blot and electrophoretogram of MMP-2 protein. (B) Wound healing migration assay of propoxur-treated and propoxur+PD98059 treated cells (magnification, ×100). Distances migrated by treated cells were compared in three independent experiments. (C) Invasiveness of cells was quantified by Transwell assays.