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A. Survival data of C57Bl6 mice with ADAM17 antibody treatment. 8 week old C57Bl6 mice infused with AngII (1 µg/kg/min, 4 weeks) and received BAPN (1 mg/mL in drinking water, first 2 weeks) were intraperitoneally injected ADAM17 antibody A9B8 or control human IgG2 (10 mg/kg) at day 1, 7, 14 and 21. B. Telemetry recording of mean arterial blood pressure (MAP) upon 4 week infusion. Control C57Bl6 mice are sham-operated for minipump implantation (n=5).
