Figure 2.

Retinal ganglion cell (RGC) density is significantly affected by NF‐L 10H9. (a) RGC density and (b) retinal nerve fibre layer (RNFL) thickness at 15 days (group A, grey bars, n = 3 mice per group, n = 2 for isotype control) or at 20 days (group B, black bars, n = 2 mice per group) after treatment with (un)labelled NF‐L 10H9 or isotype control IgG1. (a) Only mice in group B treated with unlabelled NF‐L 10H9 showed a statistically significant reduction in RGC density compared with mice treated with unlabelled isotype control IgG1 (Student's t‐test, P < 0·05). (b) No significant differences in percentage change in RNFL thickness were observed in NF‐L 10H9‐treated mice 15 or 20 days post‐induction. *P <0·05