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. Author manuscript; available in PMC: 2019 Jan 15.
Published in final edited form as: Gene. 2017 Sep 29;640:28–42. doi: 10.1016/j.gene.2017.09.044

Figure 3.

Figure 3

Different somatic second hit FLCN mutations in multiple tumors that developed in the kidneys of a BHD patient with a germline FLCN mutation demonstrating that FLCN is a tumor suppressor gene. Histologic subtypes are color coded. Chromophobe renal carcinoma, yellow; oncocytic hybrid tumor, green; renal oncocytoma, red. LOH, loss of heterozygosity. From (Vocke et al., 2005).