Effects of repeated saline or MA injections on core body temperature. Taar1-WT and -KO mice received 4 i.p. injections (indicated by arrows) of saline or MA (2.5, 5, or 10 mg/kg), spaced 2 hr apart. Body temperature was measured every 15 min via telemetry over 8 hr in an ambient temperature of 23 ± 1°C. Data represent temperature for each genotype and treatment group (mean ± SEM) at specified time points, n = 11–21 mice per group. Time points selected for detailed analysis were 30 min after each injection. *: p < 0.05, **: p < 0.01, ***: p < 0.001, ****: p < 0.0001 compared between genotypes.