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. 2016 Aug 23;8(52):89552–89565. doi: 10.18632/oncotarget.11533

Figure 6. The effects of EGFR and Erk inhibitors on pancreatic cancer cells.

Figure 6

(A) The effect of rPeriostin on promoting growth was completely inhibited by Erlotinib and partially inhibited by SCH772984. (B) Migration of SW1990 cells was significantly reduced by treatment with Erlotinib + rPeriostin, but partially reduced by treatment with SCH772984 + rPeriostin. (C) Clone formation ability of SW1990 cells was completely inhibited by Erlotinib + rPeriostin and partially inhibited by SCH772984 + rPeriostin. (D) Proposed model for the mechanism of action of periostin. Periostin activates EGFR-Akt and EGFR-Erk-c-Myc signaling to regulate survival, metastasis, and gene expression of pancreatic cancer cells.