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. 2017 Sep 22;8(52):89824–89836. doi: 10.18632/oncotarget.21158

Figure 1. Overexpression of CYP11A1 induces androgen production and syncytiotrophoblast formation in BeWo cell line.

Figure 1

(A) Overexpression of CYP11A1 and forskolin (10 μM) treatment increase pregnenolone, progesterone and testosterone secretion in BeWo cell line. (B, C) E-cadherin staining show that overexpression of CYP11A1 could reduce E-cadherin staining intensity, indicating syncytiotrophoblast formation in BeWo cell line(60×). Cox-IV was used as mitochondrial marker. * means P < 0.05, ** means P < 0.01, *** means P < 0.001. FSK = foskolin, 3.1 = control plasmid (pcDNA-3.1), CYP = CYP11A1 over expression plasmids (pcDNA-3.1-CYP11A1).