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. 2017 Sep 22;8(52):89824–89836. doi: 10.18632/oncotarget.21158

Figure 5. Adenovirus induced CYP11A1 expression in pregnant rats induce androgen receptor (AR) mediated pathway.

Figure 5

(A) ELISA measurement result shows that the serum of CYP11A1 overexpression rat significantly increased of pregnenolone and testosterone after adenovirus injection. (B) Western blot result shows that the placenta of CYP11A1 overexpressed rat expressed higher CYP11A1. (C) Western blot result shows that androgen receptor (AR) expression is significantly increased in CYP11A1 overexpressed rat model compared with controls. (D) Beclin1expression in the CYP11A1-overexpressed rat model is significantly higher than the control group. * means P < 0.05, ** means P < 0.01, *** means P < 0.001,****means P < 0.0001.