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. 2017 Oct 4;8(52):90132–90143. doi: 10.18632/oncotarget.21487

Figure 2. SESN2 and SESN3 expression inhibits NK-92 cell activation in vitro.

Figure 2

(A) GFP expression in lentivirus-transduced NK-92 cells with or without doxycycline treatment for 48 h. Len-S2: NK-92 cells transduced with Len-S2. Len-S3: NK-92 cells transduced with Len-S3. DOX: 200 ng/ml doxycycline. This is a representative image of three independent experiments. (B) SESN2 and SESN3 protein levels in doxycycline-treated NK-92 cells. Len-C: NK-92 cells transduced with lentivirus containing no SESN sequence. Len-S2: NK-92 cells transduced with Len-S2. Len-S3: NK-92 cells transduced with Len-S3. This is a representative image of two independent experiments. (C & D) Expression of NKp44 and NKG2D on NK-92 cells after treatment with vehicle (PBS) or doxycycline. Representative dot plots were shown in (C). Statistics was shown in (D). V: vehicle. DOX: doxycycline. N=6~8 per group. *, p<0.05; **, p<0.001; ***, p<0.001.