Table 2. Main Outcomes of the Study at Different Time Points.
|
HDRS |
||||||
|---|---|---|---|---|---|---|
| Baseline | Week 1 | Week 2 | Week 4 | Week 6 | Week 8 | |
| Sham | ||||||
| PP | 25.32 (3.76) | 21.83 (6.67) | 19.39 (7.42) | 18.26 (9.88) | 18.56 (10.11) | 18.56 (9.64) |
| ITT | 25.32 (3.76) | 22.2 (5.84) | 20 (7.5) | 18.96 (9.83) | 19.24 (10.02) | 19.24 (9.59) |
| dTMS | ||||||
| PP | 25.8 (5.25) | 20.36 (5.72) | 15.56 (8.22) | 13.5 (9.41) | 13.43 (10.91) | 15.95 (11.20) |
| ITT | 25.8 (5.25) | 20.36 (5.72) | 15.68 (7.9) | 14.08 (8.99) | 14.04 (10.13) | 16.48 (10.17) |
| Contrast (difference (95% CI); p | ||||||
| PP | 0.48 (−3.97–4.93); p=0.83 | −1.61 (−6.09–2.87); p=0.48 | −4.18 (−8.74–0.38); p=0.07 | −5.03 (−9.62–−0.45); p=0.03 | −5.54 (−10.16–−0.92); p=0.01 | −2.79 (−7.44–1.85); p=0.23 |
| ITT | 0.48 (−3.96–4.92); p=0.83 | −1.84 (−6.28–2.60); p=0.41 | −4.32 (−8.76–0.12); p=0.056 | −4.88 (−9.32–−0.43); p=0.03 | −5.2 (−9.64–−0.75); p=0.02 | −2.76 (−7.20–1.68); p=0.22 |
Abbreviations: dTMS, deep transcranial magnetic stimulation; PP, per protocol analyses; ITT, intention to treat analyses.
p values represent results for the mixed model ANOVA time × group interaction (for the main analysis) or time × dTMS (for the factorial analysis) interaction at each week; values in bold represent significant interactions at a p⩽0.05 level.