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. 2017 Jul 29;8(51):88488–88500. doi: 10.18632/oncotarget.19691

Figure 6. Dopamine suppressed the inflammatory response by partially regulating MAPK signaling by targeting p-p38 and p-JNK in glioma.

Figure 6

(A) Dopamine suppressed P38 and JNK MAPK phosphorylation in U87MG cells. (B) Effects of P38 and JNK inhibitors (SB203580 and SP600125) on the suppression of NF-κB expression and TNF-α and IL-6 production in glioma cells. The cells were incubated with the P38 and JNK inhibitors at the indicated concentrations for 24 h. After the cells had incubated for 24 h, the cell lysates were collected to test NF-κB expression levels in each group. In addition, the supernatant was collected, and proinflammatory cytokine levels were measured by ELISA. *P < 0.01 and **P < 0.01 compared with the control cultures. n = 3. (C) The anti-inflammatory mechanism through which dopamine exerts its effects on the NF-κB signaling pathway.