Table 6. miRNA expression either in lung or blood serum of 7.5-month old Swiss mice of both genders exposed to MCS during the first 4 months of life and treated with aspirin after weaning, as related to the presence of lung adenomas.

miRNA	Lung	Blood	Main regulated functions
miR-30e	0. 08		Intercellular adhesion, protein repair, NFkB activation, cell cycle, EGF activation, stem cell recruitment, multidrug resistance
miR-32	0.44		Apoptosis
miR-181b	0.35		NFkB stress response, cell proliferation, k-Ras suppression
miR-183		1.74	Adhesion and MAPK signaling, regulation of the tumor suppressor PTEN, cell proliferation (targeting FOXO3a, p27Kip1, and p21Cip1)
miR-301a	0.36		Targets PTEN and activates the Wnt/b-catenin pathway
miR-350	0.39		Inflammation (increase in unphosphorylated NFATc3 and its nuclear translocation)
miR-380	0.14		Represses p53 to control cell survival
miR-466a	0.29		Cell proliferation, k-Ras activation, apoptosis, protein repair, cell proliferation
miR-466i	0.39		Involved in fatty acid metabolism
miR-543	0.15		Stress response, inflammation

The numbers indicate the ratio of miRNA expression (fold-variation) between adenoma-bearing vs adenoma-free mice.