Table 2. Combination index (CI) of JQ1 and ABT-263 in H526 cells.
JQ1 dose (nM) | ABT-263 dose (nM) | Mean growth inhibition (%) | Dose of JQ1 alone with same inhibition (nM) | Dose of ABT-263 alone with same inhibition (nM) | CI |
---|---|---|---|---|---|
D1 | D2 | X | Dx1 | Dx2 | |
50 | 10 | 63.9 | 575 | 2454 | 0.004 |
50 | 100 | 78.6 | 1621 | 5248 | 0.049 |
100 | 200 | 87.8 | 1698 | 6025 | 0.092 |
200 | 50 | 94.7 | 2238 | 8511 | 0.094 |
200 | 200 | 99.8 | 10964 | 11220 | 0.035 |