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. 2017 Sep 23;8(49):86566–86575. doi: 10.18632/oncotarget.21243

Figure 2. Analysis of the fundamental mechanisms of anti-proliferation and apoptosis triggered by anti-EGFR-GN combined with NIR-PTT.

Figure 2

(A and C) Western blot of heat shock proteins (HSP90, HSP70), EGFR, Ki-67, cleaved caspase-3 and EGFR-mediated intracellular signaling molecules (mTOR, FAK, AKT, ERK1/2) in MDA-MB-231 cells treated with GN (1.84 μg/ml), anti-EGFR-GN (1.84 μg/ml GN, 0.22 μg/ml anti-EGFR-antibody) and anti-EGFR antibody (0.22 μg/ml) for 24 h and subsequent NIR-PTT for 3 min. (B and D) Data (mean±S.E., n=3) obtained from western blot experiments. **P < 0.01, ***P < 0.001.