Abstract
BACKGROUND
Treatments for gliomas are complex even though there are guidelines could be followed since variety of patient selection and doctor’s decision.
METHODS
Between January 2000 and December 2014, all glioma patients firstly surgically treated at the Sun Yat-sen University Cancer Center were retrospectively reviewed (All the patients were pathologically confirmed gliomas). The patients were then followed by real-world treatment. With follow-up to end of 2015，Survival was estimated by Kaplan-Meier analysis.
RESULTS
Among 525 patients, 35 (6.7%) were diagnosed with WHO grade Ⅰ gliomas, 129 (24.6%) with grade Ⅱ gliomas, 162 (30.9%) with grade Ⅲ gliomas and 199 (37.9%) with glioblastomas, respectively. All the patients were treated with surgery, of 186 patients who received postoperative radiotherapy, 125 were high-grade gliomas (WHO grades Ⅲ and Ⅳ) and 61 were low-grade gliomas (WHO grades Ⅰ and Ⅱ). Among 138 who received adjuvant chemotherapy, 113 were high-grade gliomas and 25 were low-grade gliomas. The 1-, 3- and 5-year overall survival of 525 patients was 79.3%, 53.9% and 45.5%, respectively. The 5-year overall survival of the patients with gliomas of WHO grade Ⅰ, Ⅱ, Ⅲ and Ⅳ was 90.2%, 61.1%, 43.6% and 26.4%.
CONCLUSIONS
In comparison with the literature reports, the prognosis of glioma patients treated at our cancer center, are much better especially the 5-year survival rate of the high-grade gliomas. Key words: Glioma; Overall survival; Real-world treatment.