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. 2017 Sep 26;7(17):4135–4148. doi: 10.7150/thno.20955

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Kinetics, liver targeting and effect on STAT3 activity of liposIA. (A) Time course of liposN, pIL-22, liposIL-22, liposIA intramuscular injection and blood sample collection. (B) IL-22 serum levels in C57BL/6 mice after a single dose injection with 0.5 mg (contains 38.5 µg plasmid) of liposIA, liposIL-22, pIL-22, liposN or PBS (n = 5; mean ± SD). (C, D) IL-22 concentrations measured by ELISA in selected organs (heart, liver, lungs, spleen, kidney and brain) at 1 or 2 days. (E) Signaling transductions activated by liposIA were analyzed by western blot against phosphorylated and total protein levels of STAT3, actin levels were shown as loading control. (F) Densitometric values of p-STAT3 were quantified and normalized to control (n = 3; mean ± SD; *P < 0.05, **P < 0.01). The values of control were set to 1.