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Biodegradable PLGA implants for sustained intratumoral delivery of Talazoparib. A) Schematic depiction of PLGA implant degradation (blue) for localized delivery of Talazoparib (red). B) Scanning Electron Microscopy images of flash-frozen and fractured, drug-loaded PLGA implants a solid smooth surface with nanoscale pores homogenously spread throughout surface of implant. C) In vitro release profile of Talazoparib from 2 mm PLGA implants (n=3) in phosphate buffered saline (pH 6.0).
