Skip to main content
. 2017 Sep 26;7(17):4340–4349. doi: 10.7150/thno.18563

Figure 3.

Figure 3

Treatment with 50 µg Talazoparib implants decreases tumor size and slows tumor growth in Brca1-deficient mice. Implants (2 mm × 0.8 mm diameter) containing 0 µg (control) or 50 µg Talazoparib were injected into established mammary gland tumors in female BrcaCo/Co;MMTV-Cre;p53+/- mice. Mice treated by oral gavage received 6 doses of Talazoparib (50 µg Talazoparib total). A) Average tumor volumes before and after treatment (n=5-8/group). *, P < 0.05 vs. initial tumor volume; ǂ, P < 0.05 vs. all other groups. B) Change in tumor volume over a period of 28 days. C) Average body weight before and after treatment (* P < 0.05 vs. initial weight for the treatment group.