Table 2. Association of the selected SNPs with colorectal cancer risk in Stage 1.
| Variable | Case (%) (n=320) | Control (%) (n=319) | Model 1 a | Model 2 b | P-value c |
|---|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | ||||
| rs4102217 (PHWE= 0.20) | |||||
| Codominant model | |||||
| GG | 235 (73.67) | 246 (77.12) | 1.00 | 1.00 | |
| GC | 79 (24.76) | 71 (22.26) | 1.16 (0.81-1.68) | 1.14 (0.78-1.66) | 0.506 |
| CC | 5 (1.57) | 2 (0.63) | - | - | - |
| Dominant model | |||||
| GG | 235 (73.67) | 246 (77.12) | 1.00 | 1.00 | |
| GC+CC | 84 (26.33) | 73 (22.88) | 1.20 (0.84-1.73) | 1.19 (0.82-1.73) | 0.366 |
| Recessive model | |||||
| GG+GC | 314 (98.43) | 317 (99.37) | 1.00 | 1.00 | |
| CC | 5 (1.57) | 2 (0.63) | - | - | - |
| rs591291 (PHWE= 0.63) | |||||
| Codominant model | |||||
| CC | 119 (37.42) | 112 (35.44) | 1.00 | 1.00 | |
| CT | 150 (47.17) | 156 (49.37) | 0.90 (0.64-1.27) | 0.86 (0.60-1.24) | 0.421 |
| TT | 49 (15.41) | 48 (15.19) | 0.96 (0.60-1.54) | 0.93 (0.57-1.52) | 0.762 |
| Dominant model | |||||
| CC | 119 (37.42) | 112 (35.44) | 1.00 | 1.00 | |
| CT+TT | 199 (62.58) | 204 (64.56) | 0.92 (0.66-1.27 | 0.88 (0.63-1.23) | 0.453 |
| Recessive model | |||||
| CC+CT | 269 (84.59) | 268 (84.81) | 1.00 | 1.00 | |
| TT | 49 (15.41) | 48 (15.19) | 1.02 (0.66-1.57) | 1.01 (0.64-1.58) | 0.977 |
| rs1194338 (PHWE= 0.02) | |||||
| Codominant model | |||||
| CC | 152 (47.50) | 134 (42.54) | 1.00 | 1.00 | |
| CA | 141 (44.06) | 157 (49.84) | 0.79 (0.57-1.10) | 0.75 (0.54-1.06) | 0.101 |
| AA | 27 (8.44) | 24 (7.62) | 0.99 (0.55-1.80) | 0.86 (0.46-1.61) | 0.639 |
| Dominant model | |||||
| CC | 152 (47.50) | 134 (42.54) | 1.00 | 1.00 | |
| CA+AA | 168 (52.50) | 181 (57.46) | 0.82 (0.60-1.12) | 0.77 (0.55-1.06) | 0.113 |
| Recessive model | |||||
| CC+CA | 293 (91.56) | 291 (92.38) | 1.00 | 1.00 | |
| AA | 27 (8.44) | 24 (7.62) | 1.11 (0.63-1.98) | 1.00 (0.55-1.82) | 0.992 |
| rs600231 (PHWE= 0.44) | |||||
| Codominant model | |||||
| AA | 118 (36.88) | 111 (34.91) | 1.00 | 1.00 | |
| AG | 152 (47.50) | 160 (50.31) | 0.89 (0.64-1.26) | 0.83 (0.58-1.19) | 0.320 |
| GG | 50 (15.62) | 47 (14.78) | 1.00 (0.62-1.61) | 0.94 (0.57-1.54) | 0.798 |
| Dominant model | |||||
| AA | 118 (36.88) | 111 (34.91) | 1.00 | 1.00 | |
| AG+GG | 202 (63.12) | 207 (65.09) | 0.92 (0.66-1.27) | 0.86 (0.61-1.20) | 0.376 |
| Recessive model | |||||
| AA+AG | 270 (84.38) | 271 (85.22) | 1.00 | 1.00 | |
| GG | 50 (15.62) | 47 (14.78) | 1.06 (0.69-1.64) | 1.04 (0.66-1.63) | 0.864 |
HWE, Hardy-Weinberg equilibrium
a Crude Model
b Adjusted for age, gender, BMI, smoking, alcohol and tea drinking
c P-value for adjusted model