Abstract
Flammer syndrome (FS) is a prevalent and mostly benign condition. Subjects with FS seem to have a good life expectancy. Nevertheless, FS subjects are at increased risk for certain diseases, mainly when they are challenged by psychological stress or other stimuli such as coldness. FS is related to ocular diseases, such as normal-tension glaucoma, retinitis pigmentosa, central serous chorioretinopathy, optic nerve compartment syndrome, Leber’s hereditary optic neuropathy, arterial or venous occlusions in the retina, and choroid and optic nerve head, despite the absence of classical vascular risk factors. FS is also related to some non-ocular diseases, such as multiple sclerosis, breast cancer, and altitude sickness. The role of FS in other diseases such as tinnitus, sudden hearing loss, Ménière’s disease, anorexia nervosa, and thyroid dysfunction is currently under investigation. The exact relationship of FS to related diseases however still needs to be established. This may hopefully lead to more targeted diagnostics and personalized treatments.
Keywords: Primary vascular dysregulation, Retinitis pigmentosa, Leber’s hereditary optic neuropathy, Arterial and vein occlusions, Multiple sclerosis, Tinnitus, Predictive preventive personalized medicine
Introduction
Flammer syndrome (FS) describes the phenotype of people with a predisposition for an altered reaction of the blood vessels to stimuli like coldness, emotional stress, or hypoxia, together with a group of signs and symptoms, as described previously [1–3]. At least in Europe, the syndrome occurs more often in women than men, in academics more often than in blue-collar workers, and in indoor, more than outdoor workers [4].
The essential component of the FS is primary dysregulation of blood vessels [2]. The term Flammer syndrome [1] was introduced in the scientific literature only recently [1, 5, 6]. Therefore, some aspects described here were labeled in previous publications as vasospasm or primary vascular dysregulation.
Flammer syndrome in healthy people
Most individuals with FS are healthy, even notably physically and mentally active and usually successful in their professional lives. They normally do not feel sick, because for them, symptoms have more or less always been present, and often their mother or father had the same. Although FS symptoms can be troublesome, FS people normally learn to deal with them, for example, by avoiding coldness, putting on socks at night, increasing salt intake, or adapting doses of drugs.
Flammer syndrome as a protective factor
Based on clinical experience, FS subjects have a good life expectancy. This can be explained by the low frequency of classical cardiovascular risk factors such as arterial hypertension, hypercholesterolemia, obesity, or diabetes. However, people with increased cold sensitivity in the extremities are additionally protected against metabolic syndrome, probably by an increased level of adiponectin [7]. Nevertheless, FS can be a risk factor for some diseases discussed in this review.
Flammer syndrome and eyes
A number of ocular signs and even ocular diseases occur more often in subjects with FS [1, 2] than in subjects without FS. While the statistical association is mostly clear, the causal relationship often remains to be established.
Ocular signs in FS subjects
On average, subjects with FS have reduced or sometimes even missing vascular response to flickering light [8]. Light stimulation of the retina increases blood flow in the smaller retinal vessels (neurovascular coupling) and thereby induces vasodilation in the larger retinal vessels via so-called flow-mediated vasodilation, mediated by the vascular endothelial cells. A reduced response to flickering light, therefore, is an indirect sign of an endotheliopathy. The retinal vessels of FS subjects also exhibit increased spatial vascular irregularity [9], indicating that the dysregulation is not homogeneous along these vessels.
Optic disc hemorrhages, classically observed in patients with glaucoma, particularly normal-tension glaucoma (NTG), occur more frequent in FS patients, sometimes even without glaucoma [10]. J. Flammer first formulated the hypothesis that this is a consequence of a weakened blood-retinal barrier [11]. In subjects with FS, the retinal astrocytes (and most probably the astrocytes in the optic nerve head) are more often or more extensively activated [12]. J. Flammer suggested that activated astrocytes increase the backscatter of light and can therefore be observed clinically in red-free light [12]. Astrocytes also play an important role in neurovascular coupling [13], and therefore their activation may further contribute to the attenuation of the response to flickering light. Astrocytes have their own hemoglobin system [14] for the transport of oxygen from the vessels to the neural axons. When activated, this oxygen transport is reduced, leading to hypoxia in the axons, while the oxygen saturation in the retinal veins increases [15]. Retinal venous pressure is, on average, slightly increased in healthy FS subjects but markedly increased in glaucoma patients with FS [16]. Subjects with FS and particularly glaucoma patients with FS often indicate pain, mostly localized behind the upper lid [17]. This can be explained by a relative hypoxia in the ciliary muscle and the increased pain sensitivity of FS subjects [2]. Rare but very disturbing are scintillations noticed when the eyes are open or closed. FS subjects sometimes describe visual disturbances after sexual activity, lasting for several hours (unpublished data).
Ocular diseases related to FS
Glaucomatous optic neuropathy
FS is one of the risk factors for glaucomatous optic neuropathy (GON) [18–21]. GON is characterized by a loss of neuronal axons and tissue remodeling, resulting in optic nerve head excavation and visual field loss. Primary vascular dysregulation, the essential component of FS, leads to hypoxia, and—even more important—to instable blood flow, which in turn locally increases oxidative stress, an essential component of the pathogenesis of GON. Ocular perfusion in FS subjects is low due to the following facts: low blood pressure, increased vascular resistance, and increased retinal venous pressure; and in addition, is unstable, due to disturbed autoregulation. This pathogenetic concept of J. Flammer has been described in previous reviews [22, 23]. Clinically, such patients with FS can be recognized by symptoms of FS, but often, in the case of glaucoma, by the typical appearance of the optic nerve head, in which the retinal vessels of the optic nerve head are less shifted to the nasal side [5] than in patients with other types of glaucoma.
Retinitis pigmentosa
Retinitis pigmentosa (RP) refers to a group of hereditary diseases of the posterior segment of the eye characterized by degeneration of rod and cone photoreceptor cells and the loss of retinal pigment epithelium function. The main symptoms are night blindness and progressive visual field loss, leading to tunnel vision and eventually blindness.
There is a relationship between RP and FS [24–26]. Even though RP has a clear genetic background [27], additional factors can influence the manifestation and progression of the disease [24]. One potential modifying factor is reduced ocular blood flow [28, 29]. Part of this is obviously secondary to tissue atrophy. The fact, however, that blood flow reduction already occurs in the early stages of the disease [30] and is not confined to the eye [28] is an indicator for an additional, primary component. We hypothesized that primary vascular dysregulation or FS, respectively, may be a major cause of this primary component of blood flow reduction [28]. Indeed, recent studies found a relationship between RP and FS [25, 26]. Again, the oxidative stress, induced by the unstable blood flow, might play an important role.
Vascular occlusions
Retinal arterial occlusions
The classic causes for arterial occlusions are emboli or atherosclerosis and other structural diseases of the blood vessels. Sometimes, however, occlusions occur even in young patients and despite the absence of such risk factors, but in the presence of FS. These occlusions often affect the optic nerve head [31], and less often, the choroid [32], cilioretinal vessel [33], and the retina [2]. Such occlusions are often triggered by major emotional stress. A relationship between Susac syndrome and FS has also been described [34]. Retinal and optic nerve head infarctions have also been described as a perioperative complication in FS patients [35, 36].
Retinal vein occlusions
While in the older literature, a retinal vein occlusion was considered to be always a consequence of a thrombosis; J. Flammer hypothesized that it may also be a consequence of a constriction of a retinal vein [37, 38]. There are several causes for such a constriction; the FS is one of them, particularly in younger patients [37]. While a mild constriction just increases the retinal venous pressure, a more pronounced constriction leads to the clinical picture of a retinal vein occlusion [38, 39]. These venous constrictions are induced by vasoconstrictive molecules such as endothelin-1. These molecules can diffuse to the veins from neighboring sick arteries or from circulating blood via fenestrated choriocapillaries into the optic nerve head and adjacent tissue. Endothelin is also produced by local hypoxic tissue. This explains why not just arteriosclerosis, systemic hypertension, and ocular hypertension but also FS increase the risk for vein occlusions.
Central serous chorioretinopathy
Central serous chorioretinopathy is a disease characterized by serous retinal detachment and/or retinal pigment epithelial detachment, particularly in the area of the macula, due to leakage of fluid through the retinal pigment epithelium into the subretinal space.
Central serous chorioretinopathy is accompanied by a local vascular dysfunction of the choroid, particularly dilated veins [40]. The cause of this vascular dysfunction is not yet clear. It has been reported to occur more often in Type-A personalities and manifests itself particularly when patients are under stress. Based on our clinical experience, the endothelin-1 plasma level rises markedly in the acute phase and then returns to nearly normal levels within days or weeks. Most, but not all of our patients with central serous chorioretinopathy suffered from FS.
Optic nerve compartment syndrome
Optic nerve compartment syndrome [41, 42] is a pathological condition in which cerebrospinal fluid of the subarachnoid space surrounding the optic nerve is partially or totally segregated from the cerebrospinal fluid of the intracranial subarachnoid space, leading, inter alia, to an increase in pressure and thereby also an increase in the diameter of the optic nerve sheath.
The pathogenesis of this condition is not yet clear. In our clinical experience, the majority of patients with the combination of optic nerve compartment syndrome and glaucoma also suffer from FS [2, 42]. FS, via unstable blood flow, increases oxidative stress and thereby may contribute to swelling of the arachnoid trabeculae, septa, and pillars in the subarachnoidal space of the optic nerve. FS may also reduce the outflow of cerebrospinal fluid through the lymphatic vessels. This would explain why treatment of FS with a calcium channel blocker also reduces the extension of the optic nerve sheath diameter in such patients [43].
Leber’s hereditary optic neuropathy
Leber’s hereditary optic neuropathy (LHON) is a maternally inherited disorder resulting from point mutations in mitochondrial DNA (mtDNA). The condition can lead to acute or subacute visual loss starting in one eye and involving the other eye after some latency. At the late stage, the optic nerve head is pale with some glaucoma-like excavation. This stimulated discussions whether there might be a potential relationship between LHON and normal-tension glaucoma [44]. Mitochondrial dysfunction is a major component in both diseases, in LOHN due to an mtDNA mutation and in NTG due to oxidative stress induced by unstable oxygen supply. The majority of LHON patients we saw also had FS [2, 45]. We assume that the unstable oxygen supply in FS subjects not only contributes to the development of GON but also increases the risk that the genotype of mtDNA mutations manifests as phenotype of LOHN [45].
Flammer syndrome and other diseases
Systemic signs and symptoms of FS
The most prominent, but not mandatory, signs and symptoms of FS are cold hands and/or feet with an increased response to coldness [46] and arterial hypotension [47]. FS subjects often have a low body-mass-index [48]. On average, they need longer to fall asleep and exhibit a phase delay of the circadian rhythm by approximately one hour. They often have a reduced feeling of thirst. This may be due to a slightly increased level of endothelin-1 in circulating blood [49], as endothelin suppresses the thirst center in the brain. FS subjects are generally more sensitive; they have for example increased sensitivity to certain drugs, increased pain sensation, increased smell sensation, and increased sensitivity to high altitude. FS subjects have more frequent headaches and migraines. FS and migraines, however, are two distinct entities that should not be confounded. FS subjects often suffer from tinnitus and have a tendency toward perfectionism. Blood flow cessation in the nailfold capillaries after cold provocation is prolonged. FS subjects have an autonomic imbalance with sympathetic predominance [50]. Nevertheless, the causal relationship with the vascular dysregulation is unclear, as non-autonomic innervated retinal vessels are also involved in FS [2]. FS subjects have altered gene expression [51] and increased systemic oxidative stress [52]. For more details, please refer to previous reviews [1, 2] and other articles in this issue.
Non-ocular diseases related to FS
Multiple sclerosis
Multiple sclerosis (MS) is a chronic, demyelinating, degenerative disease of the central nervous system of unknown etiology. MS patients suffer significantly more often from FS signs and symptoms than do controls [2, 53]. The cause of this relationship remains unknown at the moment. There are two possibilities: MS may induce FS symptoms, or FS subjects may have a higher risk of developing MS. Interestingly, MS patients often indicate they had symptoms of FS before they suffered from MS. J. Flammer et al. hypothesized that FS may sometimes lead to clinically undetected microinfarctions in the central nervous system, which then potentially trigger an autoimmune disease [2]. FS also leads to increased oxidative stress, which in turn could contribute to the pathogenesis of MS. In a later stage of the disease, the inflammations induce a secondary vascular dysregulation which further contributes to the chronic progression of MS [54].
Breast cancer and metastatic disease
The relationship between breast cancer and FS is being discussed and investigated [55] and some findings are presented in this special issue. Hypoxia and oxidative stress due to FS may predispose to breast cancer development and progression into aggressive metastatic disease [56–59]
Altitude sickness
Altitude sickness is a general term which encompasses a spectrum of disorders that occur at higher altitudes. The primary cause is the low oxygen level at higher altitude that leads to tissue hypoxia and thereby to an increase of HIF-1 α. This leads to increased expression of several hormones, including erythropoietin and endothelin-1. FS subjects not only have higher plasma endothelin level but also higher sensitivity to endothelin [60]. Symptoms of altitude sickness are more pronounced in FS subjects [2, 61, 62].
Under investigation
Tinnitus, sudden hearing loss
Clinical experience indicates that FS is also often related to tinnitus, sudden hearing loss, and even Ménière’s disease. These potential relationships are presently under investigation.
Anorexia nervosa
Clinical experience indicates that FS signs and symptoms often occur in patients with anorexia nervosa. This relationship is currently under investigation. Interestingly, fasting intensifies symptoms in FS subjects, which is in line with the observation that fasting reduces the responses of retinal vessels to flickering light [63].
Thyroid dysfunction
Thyroid diseases and dysfunctions are often observed in patients with NTG. Hypothyroidism can be associated with vascular dysfunction such as impaired endothelial- and non-endothelial-mediated vasodilation. We often found antibodies against thyroid gland in euthyroid patients suffering from the combination of NTG with FS. Some glaucoma patients with FS also suffer from Hashimoto thyroiditis.
The causal relationship between thyroid dysfunction and FS is not yet clear. FS may lead to subclinical microinfarction, triggering autoimmunity.
Heart diseases
Prinzmetal angina is a vasospastic disease occurring mostly in younger patients. A relationship with FS is likely, but has not yet been studied. Already known however is the fact that FS subjects often suffer from silent myocardial ischemia [2].
Whiplash trauma
A whiplash injury is the result of the sudden deceleration or acceleration of the thorax independent of head movement. This type of injury is commonly associated with motor vehicle collisions. As a result of the acceleration/deceleration motion, it is thought that patients may sustain bony or soft tissue injuries. Symptoms caused by the injury are grouped together as “whiplash associated disorders” and encompass neck pain, headaches, dizziness, and sleep disturbances.
We made a clinical observation that patients with whiplash trauma had more and longer-lasting symptoms when they suffered from FS.
Conclusion
While FS rather protects against certain diseases like metabolic syndrome and its related vascular events, it predisposes for some other diseases, particularly eye diseases.
It remains open at present whether treatment of FS will reduce the risk for such diseases or will slow down its progression. If this is the case, this will lead to predictive diagnostics and preventive treatment tailored to the person.
List of abbreviations: FS, Flammer syndrome; GON, glaucomatous optic neuropathy; LHON, Leber’s hereditary optic neuropathy; MS, multiple sclerosis; NTG, normal-tension glaucoma; RP, retinitis pigmentosa
Acknowledgements
The authors thank Dr Norbert Spirig, division director, University Hospital Basel for his generous support.
Authors’ contributions
K. Konieczka and C. Erb wrote the manuscript.
Compliance with ethical standards
Competing interests
The authors declare that they have no competing interests.
Additional information on authors
K. Konieczka is a glaucoma specialist, Department of Ophthalmology, University of Basel, Switzerland.
C. Erb is a glaucoma specialist, Eye Clinic Wittenbergplatz, Berlin, Germany.
References
- 1.Konieczka K, Ritch R, Traverso CE, Kim DM, Kook MS, Gallino A, et al. Flammer syndrome. EPMA J. 2014;5:11. doi: 10.1186/1878-5085-5-11. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Flammer J, Konieczka K, Flammer AJ. The primary vascular dysregulation syndrome: implications for eye diseases. EPMA J. 2013;4:14. doi: 10.1186/1878-5085-4-14. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Flammer J, Konieczka K, Bruno RM, Virdis A, Flammer AJ, Taddei S. The eye and the heart. Eur Heart J. 2013;34:1270–1278. doi: 10.1093/eurheartj/eht023. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Weller RB. Sunlight has cardiovascular benefits independently of vitamin D. Blood Purif. 2016;41:130–134. doi: 10.1159/000441266. [DOI] [PubMed] [Google Scholar]
- 5.Konieczka K, Fränkl S. Primäre vaskuläre dysregulation und glaukom (primary vascular dysregulation and glaucoma). Z Prakt Augenheilkd. 2013;34:207–15.
- 6.Konieczka K. Flammer Syndrom. In: Brähler E, Hoefert H-W, editors. Lexikon der Modernen Krankheiten. Berlin: Medizinisch Wissenschaftliche Verlagsgesellschaft; 2014. [Google Scholar]
- 7.Park AY, Cha S. Effects of cold sensitivity in the extremities on circulating adiponectin levels and metabolic syndrome in women. BMC Complement Altern Med. 2017;17:150. doi: 10.1186/s12906-017-1658-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Gugleta K, Zawinka C, Rickenbacher I, Kochkorov A, Katamay R, Flammer J, et al. Analysis of retinal vasodilation after flicker light stimulation in relation to vasospastic propensity. Invest Ophthalmol Vis Sci. 2006;47:4034–4041. doi: 10.1167/iovs.06-0351. [DOI] [PubMed] [Google Scholar]
- 9.Kochkorov A, Gugleta K, Zawinka C, Katamay R, Flammer J, Orgul S. Short-term retinal vessel diameter variability in relation to the history of cold extremities. Invest Ophthalmol Vis Sci. 2006;47:4026–4033. doi: 10.1167/iovs.06-0177. [DOI] [PubMed] [Google Scholar]
- 10.Grieshaber MC, Terhorst T, Flammer J. The pathogenesis of optic disc splinter haemorrhages: a new hypothesis. Acta Ophthalmol Scand. 2006;84:62–68. doi: 10.1111/j.1600-0420.2005.00590.x. [DOI] [PubMed] [Google Scholar]
- 11.Grieshaber MC, Flammer J. Does the blood-brain barrier play a role in glaucoma? Surv Ophthalmol. 2007;52(Suppl 2):S115–S121. doi: 10.1016/j.survophthal.2007.08.005. [DOI] [PubMed] [Google Scholar]
- 12.Grieshaber MC, Orgul S, Schoetzau A, Flammer J. Relationship between retinal glial cell activation in glaucoma and vascular dysregulation. J Glaucoma. 2007;16:215–219. doi: 10.1097/IJG.0b013e31802d045a. [DOI] [PubMed] [Google Scholar]
- 13.Filosa JA, Morrison HW, Iddings JA, Du W, Kim KJ. Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone. Neuroscience. 2016;323:96–109. doi: 10.1016/j.neuroscience.2015.03.064. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14.Tezel G, Yang X, Luo C, Cai J, Kain AD, Powell DW, et al. Hemoglobin expression and regulation in glaucoma: insights into retinal ganglion cell oxygenation. Invest Ophthalmol Vis Sci. 2010;51:907–919. doi: 10.1167/iovs.09-4014. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.Flammer J, Konieczka K. The discovery of the Flammer syndrome: a historical and personal perspective. EPMA J. 2017;8:75–97. doi: 10.1007/s13167-017-0090-x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16.Fang L, Baertschi M, Mozaffarieh M. The effect of flammer-syndrome on retinal venous pressure. BMC Ophthalmol. 2014;14:121. doi: 10.1186/1471-2415-14-121. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 17.Flammer J, Haefliger IO, Orgul S, Resink T. Vascular dysregulation: a principal risk factor for glaucomatous damage? J Glaucoma. 1999;8:212–219. doi: 10.1097/00061198-199906000-00012. [DOI] [PubMed] [Google Scholar]
- 18.Flammer J, Orgul S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, et al. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res. 2002;21:359–393. doi: 10.1016/S1350-9462(02)00008-3. [DOI] [PubMed] [Google Scholar]
- 19.Konieczka K, Frankl S, Todorova MG, Henrich PB. Unstable oxygen supply and glaucoma. Klin Monatsbl Augenheilkd. 2014;231:121–126. doi: 10.1055/s-0033-1360242. [DOI] [PubMed] [Google Scholar]
- 20.Gasser P, Flammer J. Blood-cell velocity in the nailfold capillaries of patients with normal-tension and high-tension glaucoma. Am J Ophthalmol. 1991;111:585–588. doi: 10.1016/S0002-9394(14)73703-1. [DOI] [PubMed] [Google Scholar]
- 21.Konieczka K, Choi HJ, Koch S, Fankhauser F, Schoetzau A, Kim DM. Relationship between normal tension glaucoma and Flammer syndrome. EPMA J. 2017;8:111–117. doi: 10.1007/s13167-017-0097-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 22.Flammer J, Mozaffarieh M. What is the present pathogenetic concept of glaucomatous optic neuropathy? Surv Ophthalmol. 2007;52(Suppl 2):S162–S173. doi: 10.1016/j.survophthal.2007.08.012. [DOI] [PubMed] [Google Scholar]
- 23.Flammer J. The vascular concept of glaucoma. Surv Ophthalmol. 1994;38(Suppl):S3–S6. doi: 10.1016/0039-6257(94)90041-8. [DOI] [PubMed] [Google Scholar]
- 24.Konieczka K, Flammer AJ, Todorova M, Meyer P, Flammer J. Retinitis pigmentosa and ocular blood flow. EPMA J. 2012;3:17. doi: 10.1186/1878-5085-3-17. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 25.Konieczka K, Koch S, Schoetzau A, Todorova MG. Increased prevalence of Flammer syndrome in patients with retinitis pigmentosa. Klin Monatsbl Augenheilkd. 2016;233:448–452. doi: 10.1055/s-0041-111802. [DOI] [PubMed] [Google Scholar]
- 26.Todorova MG, Josifova T, Konieczka K. Endothelin-1 plasma levels in patients with both retinitis pigmentosa and Flammer syndrome. Klin Monatsbl Augenheilkd. 2015;232:514–518. doi: 10.1055/s-0035-1545674. [DOI] [PubMed] [Google Scholar]
- 27.Ferrari S, Di Iorio E, Barbaro V, Ponzin D, Sorrentino FS, Parmeggiani F. Retinitis pigmentosa: genes and disease mechanisms. Curr Genomics. 2011;12:238–249. doi: 10.2174/138920211795860107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 28.Cellini M, Strobbe E, Gizzi C, Campos EC. ET-1 plasma levels and ocular blood flow in retinitis pigmentosa. Can J Physiol Pharmacol. 2010;88:630–635. doi: 10.1139/Y10-036. [DOI] [PubMed] [Google Scholar]
- 29.Falsini B, Anselmi GM, Marangoni D, D’Esposito F, Fadda A, Di Renzo A, et al. Subfoveal choroidal blood flow and central retinal function in retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2011;52:1064–1069. doi: 10.1167/iovs.10-5964. [DOI] [PubMed] [Google Scholar]
- 30.Wolf S, Postgens H, Bertram B, Schulte K, Teping C, Reim M. Hemodynamic findings in patients with retinitis pigmentosa. Klin Monatsbl Augenheilkd. 1991;199:325–329. doi: 10.1055/s-2008-1046089. [DOI] [PubMed] [Google Scholar]
- 31.Gaspar AZ, Flammer J, Hendrickson P. Influence of nifedipine on the visual fields of patients with optic-nerve-head diseases. Eur J Ophthalmol. 1994;4:24–28. doi: 10.1177/112067219400400105. [DOI] [PubMed] [Google Scholar]
- 32.Terelak-Borys B, Grabska-Liberek I, Piekarniak-Wozniak A, Konieczka K. Choroidal infarction in a glaucoma patient with Flammer syndrome: a case report with a long term follow-up. BMC Ophthalmol. 2017;17:23. doi: 10.1186/s12886-017-0416-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 33.Konieczka K, Todorova MG, Chackathayil TN, Henrich PB. Cilioretinal artery occlusion in a young patient with Flammer syndrome and increased retinal venous pressure. Klin Monatsbl Augenheilkd. 2015;232:576–578. doi: 10.1055/s-0035-1545774. [DOI] [PubMed] [Google Scholar]
- 34.Flammer J, Kaiser H, Haufschild T. Susac syndrome: a vasospastic disorder? Eur J Ophthalmol. 2001;11:175–179. doi: 10.1177/112067210101100213. [DOI] [PubMed] [Google Scholar]
- 35.Bojinova RI, Konieczka K, Meyer P, Todorova MG. The trilateral link between anaesthesia, perioperative visual loss and Flammer syndrome. BMC Anesthesiol. 2016;16:10. doi: 10.1186/s12871-016-0176-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 36.Bojinova RI, Konieczka K, Todorova MG. Unilateral loss of vision after spinal surgery in a patient with Flammer syndrome. Klin Monatsbl Augenheilkd. 2016;233:429–431. doi: 10.1055/s-0041-111750. [DOI] [PubMed] [Google Scholar]
- 37.Fraenkl SA, Mozaffarieh M, Flammer J. Retinal vein occlusions: the potential impact of a dysregulation of the retinal veins. EPMA J. 2010;1:253–261. doi: 10.1007/s13167-010-0025-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 38.Flammer J, Konieczka K. Retinal venous pressure: the role of endothelin. EPMA J. 2015;6:21. doi: 10.1186/s13167-015-0043-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 39.Mozaffarieh M, Bartschi M, Henrich PB, Schoetzau A, Flammer J. Retinal venous pressure in the non-affected eye of patients with retinal vein occlusions. Graefes Arch Clin Exp Ophthalmol. 2014;252:1569–1571. doi: 10.1007/s00417-014-2617-3. [DOI] [PubMed] [Google Scholar]
- 40.Prunte C, Flammer J. Choroidal capillary and venous congestion in central serous chorioretinopathy. Am J Ophthalmol. 1996;121:26–34. doi: 10.1016/S0002-9394(14)70531-8. [DOI] [PubMed] [Google Scholar]
- 41.Killer HE. Compartment syndromes of the optic nerve and open-angle glaucoma. J Glaucoma. 2013;22(Suppl 5):S19–S20. doi: 10.1097/IJG.0b013e3182934a0f. [DOI] [PubMed] [Google Scholar]
- 42.Killer HE, Jaggi GP, Flammer J, Miller NR. Is open-angle glaucoma caused by impaired cerebrospinal fluid circulation: around the optic nerve? Clin Exp Ophthalmol. 2008;36:308–311. doi: 10.1111/j.1442-9071.2008.01735.x. [DOI] [PubMed] [Google Scholar]
- 43.Konieczka K, Todorova MG, Bojinova RI, Binggeli T, Chackathayil TN, Flammer J. Unexpected effect of calcium channel blockers on the optic nerve compartment syndrome. Klin Monatsbl Augenheilkd. 2016;233:387–390. doi: 10.1055/s-0042-102619. [DOI] [PubMed] [Google Scholar]
- 44.Opial D, Boehnke M, Tadesse S, Lietz-Partzsch A, Flammer J, Munier F, et al. Leber’s hereditary optic neuropathy mitochondrial DNA mutations in normal-tension glaucoma. Graefes Arch Clin Exp Ophthalmol. 2001;239:437–440. doi: 10.1007/s004170100309. [DOI] [PubMed] [Google Scholar]
- 45.Konieczka K, Flammer J, Sternbuch J, Binggeli T, Fraenkl S. Leber’s hereditary optic neuropathy, normal tension glaucoma, and Flammer syndrome: long term follow-up of a patient. Klin Monbl Augenheilkd. 2017;234(4):584–7. [DOI] [PubMed]
- 46.Saner H, Wurbel H, Mahler F, Flammer J, Gasser P. Microvasculatory evaluation of vasospastic syndromes. Adv Exp Med Biol. 1987;220:215–218. doi: 10.1007/978-1-4613-1927-6_38. [DOI] [PubMed] [Google Scholar]
- 47.Gherghel D, Orgul S, Gugleta K, Flammer J. Retrobulbar blood flow in glaucoma patients with nocturnal over-dipping in systemic blood pressure. Am J Ophthalmol. 2001;132:641–647. doi: 10.1016/S0002-9394(01)01193-X. [DOI] [PubMed] [Google Scholar]
- 48.Gasser P, Stumpfig D, Schotzau A, Ackermann-Liebrich U, Flammer J. Body mass index in glaucoma. J Glaucoma. 1999;8:8–11. doi: 10.1097/00061198-199902000-00004. [DOI] [PubMed] [Google Scholar]
- 49.Teuchner B, Orgul S, Ulmer H, Haufschild T, Flammer J. Reduced thirst in patients with a vasospastic syndrome. Acta Ophthalmol Scand. 2004;82:738–740. doi: 10.1111/j.1600-0420.2004.00376.x. [DOI] [PubMed] [Google Scholar]
- 50.Anders D, Vollenweider S, Cann J, Hofstetter M, Flammer J, Orgul S, et al. Heart-rate variability in women during 40-hour prolonged wakefulness. Chronobiol Int. 2010;27:1609–1628. doi: 10.3109/07420528.2010.504317. [DOI] [PubMed] [Google Scholar]
- 51.Yeghiazaryan K, Flammer J, Orgul S, Wunderlich K, Golubnitschaja O. Vasospastic individuals demonstrate significant similarity to glaucoma patients as revealed by gene expression profiling in circulating leukocytes. Mol Vis. 2009;15:2339–2348. [PMC free article] [PubMed] [Google Scholar]
- 52.Mozaffarieh M, Schoetzau A, Sauter M, Grieshaber M, Orgul S, Golubnitschaja O, et al. Comet assay analysis of single-stranded DNA breaks in circulating leukocytes of glaucoma patients. Mol Vis. 2008;14:1584–1588. [PMC free article] [PubMed] [Google Scholar]
- 53.Konieczka K, Koch S, Binggeli T, Schoetzau A, Kesselring J. Multiple sclerosis and primary vascular dysregulation (Flammer syndrome) EPMA J. 2016;7:13. doi: 10.1186/s13167-016-0062-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 54.Flammer J, Pache M, Resink T. Vasospasm, its role in the pathogenesis of diseases with particular reference to the eye. Prog Retin Eye Res. 2001;20:319–349. doi: 10.1016/S1350-9462(00)00028-8. [DOI] [PubMed] [Google Scholar]
- 55.Golubnitschaja O, Debald M, Yeghiazaryan K, Kuhn W, Pesta M, Costigliola V, et al. Breast cancer epidemic in the early twenty-first century: evaluation of risk factors, cumulative questionnaires and recommendations for preventive measures. Tumour Biol. 2016;37:12941–57. [DOI] [PubMed]
- 56.Golubnitschaja O. Feeling cold and other underestimated symptoms in breast cancer: anecdotes or individual profiles for advanced patient stratification? EPMA J. 2017;8:17–22. doi: 10.1007/s13167-017-0086-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 57.Bubnov R, Polivka J, Jr, Zubor P, Konieczka K, Golubnitschaja O. “Pre-metastatic niches” in breast cancer: are they created by or prior to the tumour onset? “Flammer syndrome” relevance to address the question. EPMA J. 2017;8:141–157. doi: 10.1007/s13167-017-0092-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 58.Zubor P, Gondova A, Polivka Jr. J, Kasajova P, Konieczka K, Danko J, Golubnitschaja O. Breast cancer and Flammer syndrome: any symptoms in common for prediction, prevention and personalised medical approach? EPMA J 2017;8(2):129–140 [DOI] [PMC free article] [PubMed]
- 59.Smokovski I, Risteski M, Polivka J Jr., Zubor P, Konieczka K, Costigliola V, Golubnitschaja O. Postmenopausal breast cancer: European challenge and innovative concepts. EPMA J. 2017;8(2):159–169 [DOI] [PMC free article] [PubMed]
- 60.Gass A, Flammer J, Linder L, Romerio SC, Gasser P, Haefeli WE. Inverse correlation between endothelin-1-induced peripheral microvascular vasoconstriction and blood pressure in glaucoma patients. Graefes Arch Clin Exp Ophthalmol. 1997;235:634–638. doi: 10.1007/BF00946939. [DOI] [PubMed] [Google Scholar]
- 61.Neumann T, Baertschi M, Vilser W, Drinda S, Franz M, Bruckmann A, et al. Retinal vessel regulation at high altitudes1. Clin Hemorheol Microcirc. 2016;63:281–292. doi: 10.3233/CH-162041. [DOI] [PubMed] [Google Scholar]
- 62.Baertschi M, Dayhaw-Barker P, Flammer J. The effect of hypoxia on intra-ocular, mean arterial, retinal venous and ocular perfusion pressures. Clin Hemorheol Microcirc. 2016;63:293–303. doi: 10.3233/CH-152025. [DOI] [PubMed] [Google Scholar]
- 63.Heitmar R, Gherghel D, Armstrong R, Cubbidge R, Hosking S. The effect of voluntary fasting and dehydration on flicker-induced retinal vascular dilation in a healthy individual: a case report. J Med Case Rep. 2008;2:153. doi: 10.1186/1752-1947-2-153. [DOI] [PMC free article] [PubMed] [Google Scholar]