Graphical user interface of 2AFC experiment shows, A, image with lesion and, B, image without lesion. For this experiment, the reader was asked to choose which image is most likely to contain the lesion. Reader outcomes (ie, detection or nondetection) were recorded for each trial and the ensemble of outcomes across all combinations of radiation dose level (n = 6), reconstruction algorithm (n = 2), reader (n = 16), and lesion (n = 105) were input into a generalized linear mixed effects statistical model to examine how these factors affected detection accuracy.