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. Author manuscript; available in PMC: 2018 Oct 19.
Published in final edited form as: Nanoscale. 2017 Oct 19;9(40):15379–15389. doi: 10.1039/c7nr02327h

Figure 4.

Figure 4

DOX loading and release in nanogels and nanocomposites. (a) Schematic representation of loading DOX in nanogels. (b) Encapsulation efficiency of DOX in 5mg nanogels. 100 µg/mL proved to be the most efficient concentration. (c) Encapsulation efficiency of 100 µg/mL DOX in various concentrations of nanogels. 5 and 10 mg nanogels provided a significant increase in loading (***p<0.001). (d) Release kinetics from nanogels were observed to be significantly greater (**p<0.01) when exposed to temperatures above the VPTT. (e) When DOX loaded nanogels were encapsulated in GelMA matrix, release was also significantly greater (*p<0.05) when exposed to temperatures above VPTT. (f) Nanocomposites were exposed to an AMF at RT for 1 hour and cumulative release was observed to be significantly greater (***p<0.001) than nanocomposites exposed to thermal stimulus.