Table 3. Main effects of PADI4 SNPs on ESCC risk.
| Genotyped SNPs | Genotyping | AB vs. AA b Adjusted ORc (95% CI); p | BB vs. AA Adjusted OR (95% CI); p | p trend | |
|---|---|---|---|---|---|
| Case (n=629) (AA/AB/BB) a | Control (n=686) (AA/AB/BB) | ||||
| PADI4: rs11203366 A>G | 219/293/103 | 214/301/138 | 1.00 (0.78–1.29);0.985 | 0.77 (0.56–1.07);0.117 | 0.128 |
| PADI4: rs1886302 T>C | 250/273/77 | 295/308/70 | 1.09 (0.86–1.39);0.487 | 1.37 (0.94–1.99);0.100 | 0.372 |
| PADI4: rs1635562 A>T | 295/251/64 | 302/285/70 | 0.90 (0.71–1.15);0.406 | 0.91 (0.62–1.34);0.632 | 0.682 |
| PADI4: rs1635564 C>A | 388/180/32 | 420/202/29 | 1.02 (0.80–1.31);0.860 | 1.22 (0.72–2.07);0.470 | 0.739 |
| PADI4: rs16825533 A>G | 528/85/6 | 560/109/7 | 0.86 (0.63–1.18);0.349 | 0.97 (0.32–2.98);0.957 | 0.477 |
| PADI4: rs2240337 G>A | 506/86/8 | 466/161/24 | 0.52 (0.39–0.71);<0.0001 | 0.30 (0.13–0.68);0.004 | <0.0001 |
| PADI4: rs2477137 C>A | 399/202/18 | 447/202/27 | 1.15 (0.90–1.47);0.256 | 0.76 (0.40–1.41);0.381 | 0.365 |
aAA/AB/BB means homozygote, heterozygote and mutated homozygote; b Bonferroni correction was performed to correct the p value (padj); For PADI4: rs2240337 G>A, the padj = 0.031 for GA vs. GG, padj < 0.001 for AA vs. GG, padj < 0.0001 for p trend. For the rest 6 SNPs, padj> 0.05 in all comparison models; Bold values are statistically significant (p <0.05); c Adjusted for age, sex, smoking and drinking status.