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. 2017 Sep 8;8(55):93757–93770. doi: 10.18632/oncotarget.20771

Figure 7. Knockdown of LC3 or Silencing for Bcl-xL reduced the deposition and improved the arrangement of collagen fibers in rabbit scar model.

Figure 7

Masson’s trichrome staining findings for collagen fibers. (A) Rabbit ear normal skin with regularly arranged, small collagen fibers. (B) Rabbit ear scar model tissue with thicker, denser and disorganized collage fibers. (C-F, H, I) In PBS, AdNT, AdLC3, shNT, siNT and sibcl-2 groups, the amount of collagen fibers is far more than that in the normal group, and collage fibers are thicker, denser and disorganized. (G, J) After treatment with shLC3 and sibcl-xL for 49 days, the collagen fibers were arranged more regularly and sparser than those in the model, PBS and corresponding control groups. n = 6 scars in each group. Scale bars, a, c-i, 100 μm; b, 250 μm, 100 μm; j, 50 μm.