Table 3. Comparison of the frequencies of solid cancers in the German MCAS patient cohort with the 10-year prevalences of these cancers in the general German population 40.
| Malignant diseases of the | 10-year prevalence in
German population |
MCAS patients; n=417 |
|---|---|---|
| Skin: melanoma | f, age 0–39 years : 0.06%
f, age > 39 years: 0.19% m, age 0–49 years: 0.05% m, age >49 years: 0.21% |
(n= 79) 0
(n=233) 1 = 0.43%, P=0.611, ns (n=60) 1 = 1.67%, P=0.0001 (n=45) 0 |
| Lung | f, age 0–49 years : 0.01%
f, age > 49 years: 0.13% m, age 0–49 years: 0.01% m, age >49 years: 0.47% |
(n=139)
1 = 0.72%, P<0.0001
(n=173) 0 (n=60) 0 (n=45) 0 |
| Stomach | f, age 0–69 years: 0.05%
f, age > 69 years: 0.26% m, age 0–59 years: 0.05% m, age > 59 years: 0.38% |
(n=283) 0
(n=28) 0 (n=83) 0 (n=23) 0 |
| Gut | f,m, age 0–59: 0.15%
f,m, age > 59 years: 1.5% |
(n=323) 0
(n=94) 0 |
| Carcinoid | f,m | f: 0.7% 2 |
| Breast | 0–39 years: < 0.01%
> 39 years: 1.7% |
(n=79)
1 = 1.3%, P=0.0025
(n=233) 7 = 3.00%, P=0.0019 |
|
Uterus:
cervix body |
0–39 years: 0.04% > 39 years: 0.16% 0–39 years: 0.05% > 39 years: 0.57% |
(n=79) 1 = 1.30%, P<0.0001 (n=233) 1 = 0.43%; P=0.4613,ns (n=79) 0 (n=233) 0 |
| Prostate | age 0–59 years: 0.1%
age >59 years: 4.2% |
(n=82) 0
(n=23) 0 |
| Testis | 0–39 years: 0.11%
> 39 years: 0.09% |
(n=42)
1 = 2.4%, P=0.050
(n=63) |
| Urinary bladder | f, age 0–59 years: 0.02%
f, age > 59 years: 0.31% m, age 0–59 years: 0.05% m, age > 59 years: 1.68% |
(n=236)
1 = 0.42%, P=0.022
(n=76) 0 (n=82) 0 (n=23) 0 |
| Thyroid gland | F, all ages : 0.10%
M, all ages: 0.32% |
(n=312) 0
(n=105) 1 = 0.2%, P=0.7780, ns |
Parentheses, number of patients in the respective age group; bold print, number of affected patients; f, female; m, male. P, two-sided P value in the Chi-square-test; ns, not significant