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. 2017 Jul 25;8(53):91085–91098. doi: 10.18632/oncotarget.19555

Figure 6. Orellanine significantly reduces tumor growth and induces necrosis.

Figure 6

Tumor volume in control rats and in rats receiving orellanine treatment, 10 mg/L for 48 hours via the dialysis solution at Day 8–9 (controls n = 5, treated n = 6). (B–C) Representative photos of hematoxylin and eosin stained tumor sections of control rats (B) and orellanine-treated rats (C), analyzed at day 16 post inoculation. (D) Necrotic area (%) of total tumor area and (E) viable tumor mass after subtraction of necrotic areas (controls n = 5, treated n = 6). (F) Representative photo of (F) control tumor and (G) orellanine-treated tumor. Data in a, d–e are presented as mean ± SEM and p-values are determined by t test, where p < 0.05 was considered significant. ***p < 0.001.