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. 2017 Nov 27;20(1):32–43. doi: 10.1016/j.neo.2017.11.002

Figure 7.

Figure 7

BIGH3 expression in RCC bone metastasis. (A) A representative X-ray from a patient showing a pathologic fracture due to bone metastasis from RCC. (B) BIGH3 expression in three specimens of human RCC bone metastasis samples (upper) and normal bone marrow (lower) was determined by IHC staining. Both H&E staining and IHC staining for BIGH3 are shown at the magnification of 40×. (C) The proposed role of BIGH3 in enhancing osteolytic bone lesions from RCC bone metastasis. RCC cells in bone secrete BIGH3 that inhibits osteoblast differentiation that would normally counterbalance osteoclast activity, thus enhancing RCC-mediated osteolytic bone destruction.