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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Neuropharmacology. 2017 Sep 14;128:1–10. doi: 10.1016/j.neuropharm.2017.09.019

Figure 4. Effect of LgA and prolonged abstinence on GLT-1 gene methylation in the NAc.

Figure 4

(A, B) Behavioral data for animals in MeDIP experiments after LgA self-administration and 45 days of withdrawal. (C) Methylation state of the GLT-1 gene in the NAc after LgA cocaine or saline self-administration and withdrawal. LgA cocaine self-administration and withdrawal induces a significant 2.75-fold increase in GLT-1 gene methylation in the NAc. *p < 0.05. +Significant difference between day 2 and day 3 of self-administration (p < 0.05).