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. Author manuscript; available in PMC: 2018 Dec 5.
Published in final edited form as: Circulation. 2017 Oct 4;136(23):2271–2283. doi: 10.1161/CIRCULATIONAHA.117.030972

Figure 3. Bone marrow reconstitution indicates a key role for vascular-specific IDO deficiency in AAA formation.

Figure 3

Apoe−/− and Apoe−/−/IDO−/− mice were reconstituted with Apoe−/− or Apoe−/−/IDO+/+ bone marrow cells, followed by 4 weeks of saline or AngII infusion (1000 ng/min per kg). (a) Representative photographs showing the macroscopic features of AngII-induced aneurysms. Arrows indicate typical AAA. (b–d) The incidence of AngII-induced AAA (b), maximal abdominal aortic diameter (c), and total aortic weight (d) in AngII-infused mice reconstituted with IDO+/+ or IDO−/− bone marrow cells. n=10–15 per group. BM, bone marrow; NS, not significant. *P<0.01 vs. AngII-infused Apoe−/− mice reconstituted with Apoe−/−/IDO+/+ bone marrow cells. P values were obtained by a Fisher exact test in b and by a two-way ANOVA with following Bonferroni’s multiple comparisons in c and d. The error bars in c and d are s.e.m.