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. 2017 Dec 6;11(12):e0006127. doi: 10.1371/journal.pntd.0006127

Correction: CD8+ T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection

Guang Xu, Nicole L Mendell, Yuejin Liang, Thomas R Shelite, Yenny Goez-Rivillas, Lynn Soong, Donald H Bouyer, David H Walker
PMCID: PMC5718426  PMID: 29211737

Fig 7A is incorrect. The label “CD8-/- Infected” should read “MHC I-/- Infected”. The authors have provided a corrected version here.

Fig 7. Histopathological comparison of MHC I-/- mice and WT mice infected with O. tsutsugamushi.

Fig 7

Foci of inflammation (arrows), including infiltration of macrophages and lymphocytes, were observed in infected mice (A, mag: 100x, 400x inset). Many apoptotic cells, possibly neutrophils, were observed in the liver of MHC I-/- mice. Increased necrosis and steatosis (arrows with circle end) were observed in the livers of MHC I-/- mice. Higher pathology scores indicating greater injury were observed in the livers of infected mice (B). There were significantly more apoptotic cells in the liver (C) and kidney (D) of MHC I-/- mice than their WT counterparts. All infected mice had increased apoptosis compared to uninfected mice. *, p<0.05; ***, p<0.001, n = 8; each tissue sample was blindly scored by four experienced investigators.

Reference


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