Table 1.
Pre-resuscitation parameters (t=22h)
| Variable | Sham (n=5) | FFP (n=14) | NS (n=14) | p-value* |
|---|---|---|---|---|
| Weight (g) | 388 ± 7 | 383 ± 30 | 381 ± 33 | 0.95 |
| ΔWeight (g)† | 0 ± 1 | −8 ± 6 | −6 ± 6 | 0.03 |
| MAP (mmHg) | 99 ± 16 | 94 ± 15 | 94 ± 16 | 0.75 |
| Heart rate (bpm) | 336 ± 40 | 428 ± 30 | 405 ± 24 | <0.01 |
| Temperature (°C) | 36.5 ± 0.5 | 35.7 ± 1.2 | 35.7 ± 0.7 | 0.12 |
| Sodium (mEq/L) | 144 ± 1 | 138 ± 4 | 137 ± 4 | <0.01 |
| Potassium (mEq/L) | 3.8 ± 0.3 | 4.7 ± 0.8 | 5.1 ± 0.7 | <0.01 |
| Chloride (mEq/L) | 97 ± 1 | 97 ± 3 | 97 ± 6 | 0.95 |
| Bicarbonate (mEq/L) | 21 ± 4 | 24 ± 5 | 23 ± 4 | 0.40 |
| BUN (mg/dL) | 14 ± 1 | 44 ± 14 | 51 ± 17 | <0.01 |
| Creatinine (mg/dL) | 0.7 ± 0.1 | 1.0 ± 0.7 | 1.2 ± 0.6 | 0.16 |
| Lactate (mEq/L) | 0.6 ± 0.3 | 3.4 ± 1.1 | 3.4 ± 0.9 | <0.01 |
| Hematocrit | 41 ± 2 | 46 ± 3 | 47 ± 4 | 0.02 |
| pH | 7.28 ± 0.03 | 7.32 ± 0.10 | 7.27 ± 0.13 | 0.37 |
| PCO2 (mmHg) | 46 ± 9 | 47 ± 10 | 51 ± 16 | 0.61 |
| PO2 (mmHg)‡ | 395 ± 43 | 413 ± 73 | 390 ± 87 | 0.72 |
| PO2 to FiO2 ratio | 403 ± 44 | 421 ± 75 | 398 ± 89 | 0.72 |
| Base excess (mEq/L) | −3.9 ± 3.5 | −1.8 ± 5.5 | −4.1 ± 5.3 | 0.47 |
*
One-way analysis of variance for 3 groups. For all p<0.05, there were no differences between FFP and NS groups on post-hoc tests.
†
Pre-resuscitation (t=22h) minus pre-CLP (t=0h) weight
‡
On 98% FiO2
MAP, mean arterial pressure; BUN, blood urea nitrogen; IL, interleukin; FFP, fresh frozen plasma; NS, normal saline; CLP, cecal ligation and puncture.