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. 2017 Nov 15;144(22):4173–4182. doi: 10.1242/dev.153700

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© 2017. Published by The Company of Biologists Ltd

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Fig. 7. — c-Myc and N-Myc are necessary for expression of Wnt/β-catenin progenitor renewal targets. Sections of E13.5 wild-type (c-Myc^flox/flox;N-Myc^flox/flox; A-E) and mutant (Six2Cre;c-Myc^flox/flox;N-Myc^flox/flox; F-J) kidneys hybridized with antisense in situ probes for the Wnt9b-independent nephron progenitor marker Six2 (A,F), the Wnt9b-dependent progenitor renewal targets Cited1 (B,G) and Fam19a5 (C,H), or the Wnt9b-dependent nephron progenitor differentiation targets C1qdc2 (D,I) and Pax8 (E,J). Arrows indicate the nephron progenitor cells and ureteric bud is outlined. Scale bars: 50 μm.