Figure 6. The current landscape of in vivo non-genetic allelic effects in mammals.

( A) Non-genetic allelic effects that impact X-linked genes in females are shown. ( B) Effects impacting autosomal genes are shown. Tissue- and age-specific allele co-expression effects for X-linked genes were observed by Huang and Ferris and colleagues ⁵³ (2017), but the underlying cause is not yet known. Additionally, the frequency of clonal random monoallelic expression (RME) effects in vivo is debated and requires further investigation.