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. 2017 Oct 23;8(57):97313–97322. doi: 10.18632/oncotarget.21960

Figure 5. MiR-204 promotes DOX-induced acetylation of p53 in Pca.

Figure 5

(A) Effect of DOX (0.5 μM), miR-204 and SIRT1 plasmid on changing the acetylation of p53 in C4-2 and LNCaP cells. (B) Knockdown of p53 abolished the effect of miR-204 on enhancing the DOX-induced (0.5 μM) cell death in C4-2 and LNCaP cells. *P<0.05 vs. DOX + NCO group, #P<0.05 vs. DOX + miR-204 group. (C) MiR-204 failed to promote the DOX-induced (0.5 μM) cell death in p53-null PC3 cells. *P<0.05 vs. NCO group. (D) MiR-204 enhanced the CDDP-induced (2 μM) cell death in C4-2 and LNCaP cells. *P<0.05 vs. CDDP + NCO group, #P<0.05 vs. CDDP + miR-204 group. (E) MiR-204 failed to promote the CDDP-induced (2 μM) cell death in p53-null PC3 cells. *P<0.05 vs. NCO group.