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. 2017 Nov 27;6:e30640. doi: 10.7554/eLife.30640

Figure 1. AKT isoform-specific expression in the hippocampus.

Figure 1.

Immunohistology using isoform-specific antibodies revealed distinct expression patterns for each AKT isoform in the hippocampus. AKT1 was mainly expressed in the cell body layers, with the greatest levels in stratum pyramidale of CA1. AKT2 was mostly expressed in specific cells in the molecular layer of the dentate gyrus, CA3 and CA1. AKT3 was also mainly expressed in the cell body layers of the hippocampus and showed strong expression in the hilus and CA3. Bottom panels show single Akt knockout (KO) tissue to validate the specificity of the antibodies.