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. 2017 Dec 8;292(49):20045. doi: 10.1074/jbc.W117.000978

Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms.

Silvia Lisa, Beatriz Domingo, Javier Martínez, Sabine Gilch, Juan F Llopis, Hermann M Schätzl, María Gasset
PMCID: PMC5723993  PMID: 29222196

VOLUME 287 (2012) PAGES 36693–36701

This article has been withdrawn by the authors. We have become aware of errors in the preparation of the following figures. There were several duplications in Fig. 2A. Lanes 2–5 of the MoPrP immunoblot from HpL cells were reused in lanes 2–5 of the HaPrP immunoblot from GpL cells. The M205S MoPrP mutant expressed in HpL cells was reused as the M212S MoPrP mutant in HpL cells. The actin immunoblot from HpL cells expressing HaPrP was reused as the actin immunoblot from GpL cells expressing MoPrP. The mock transfected lanes from GpL cells were duplicated. Finally, lanes 4 and 5 and lanes 6 and 7 of the actin immunoblot from GpL cells expressing HaPrP were duplicated. Lane 1 of Fig. 2B was duplicated in lane 2 of the same figure and lane 1 of Fig. 2C. In Fig. 2G, lanes 2 and 5 are duplicates. In Fig. 3, panels P and O were duplicated. Fig. 4A contained undeclared gel splices. However, the original data from replicated experiments performed by other lab members support the overall findings and conclusions of the study. Given the severity of figure manipulations, the authors have decided to withdraw the article. The authors sincerely apologize to the scientific community for the errors in the published article. The paper with the corrected figures can be obtained by contacting the corresponding author.


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