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. 2017 Dec 1;20(1):69–79. doi: 10.1016/j.neo.2017.11.003

Figure 4.

Figure 4

The increased cytotoxicity of NK cells to UEC cells induced by rapamycin is partly dependent on IL-27. (A, B) After co-culture with or without rapamycin (100 nM)-pretreated mock or IL-27+ Ishikawa cells, the expression of KIR2DL1, KIR3DL1, NKG2D, CD16, NKp46, Granzyme B, and perforin in NK cells (n = 6) was analyzed by FCM. (C, D) The expression of KIR2DL1, KIR3DL1, NKG2D, CD16, NKp46, Granzyme B, and perforin in PKH-67 labeled NK cells was treated as described in Figure 3G. Data are expressed as mean ± SEM. *P < .05, **P < .01, ***P < .001, and ****P < .0001.