Table 1. A. Primary vs RR mutation frequency B. by amino acid change. B. Primary vs RR mutation frequency B. by amino acid change.

A			B
Gene Symbol	% Primary	% RR	Gene Symbol	AA Change	% Primary	% RR
CREBBP	31.25%	41.67%	MYD88	L265P	8.04%	4.17%
8CL2	20.54%	37.50%	EZH2	Y646N	4.46%
TP53	21.43%	35.42%	TP53	R248Q	4.46%
MYD88	11.61%	18.75%	EZH2	Y646F	4.46%	4.17%
B2M	8.04%	18.75%	CARD11	D230N	3.57%
MYC	9.82%	14.58%	P1M1	5188N	3.57%	2.08%
EP300	13.39%	12.50%	PIM1	K115N	3.57%
BTK	5.36%	12.50%	CD798	Y196C	2.68%
P1M1	22.32%	10.42%	CREBBP	R1446C	2.68%
CARD11	16.07%	10.42%	EZH2	Y6465	2.68%
EZH2	13.39%	10.42%	CREBBP	51680de1	2.68%	6.25%
CD798	12.50%	6.25%	CREBBP	R1446H	2.68%	2.08%
BCL6	7.14%	6.25%	MYD88	5219C	1.79%	6.25%
JAK1	1.79%	6.25%	TP53	R273C	1.79%	2.08%
MALT1	1.79%	4.17%	BCL2	P59A	0.89%	8.33%