Table 4a. Progression Free Results for Non-Muscle Invasive Bladder Cancer.

	Univariate Analyses1						Multivariate Analyses1
	n	Median2	HR3	LCL	UCL	p4	n	Median2	HR3	LCL	UCL	p4
Age (years)
≤ 65	183	41.7	1.00				181	36.8	1.00
> 65	317	14.6	1.84	1.29	2.63	.0008	317	15.9	1.67	1.16	2.40	.006
Gender
Female	95	21.2	1.00				95	18.2	1.00
Male	405	22.1	0.98	0.66	1.46	.92	403	22.6	0.88	0.59	1.32	.54
Tumor Grade
Low	219	50.5	1.00				219	36.2	1.00
High	279	11.4	2.47	1.74	3.52	<.0001	279	14.5	1.74	1.04	2.92	.03
Tumor Stage
Ta or Tis	253	44.6	1.00				252	27.8	1.00
T1	247	11.0	2.34	1.68	3.27	<.0001	246	16.7	1.42	0.87	2.33	.16
Lymph Nodes
N0 or NX	487	23.5	1.00				486	22.8	1.00
N1	13	1.3	5.98	3.22	11.11	<.0001	12	2.8	4.25	2.20	8.21	<.0001
ANG
0-2	408	25.6	1.00				408	24.3	1.00
3-4	29	22.9	1.08	0.55	2.13	.83	28	26.2	0.97	0.47	2.00	.92
MMP-2
0-2	175	26.1	1.00				173	25.5	1.00
3-4	281	21.6	1.06	0.75	1.49	.75	281	20.4	1.09	0.77	1.55	.63
5-6	2	17.8	1.12	0.56	2.22		2	16.2	1.19	0.59	2.39
p53
0-2	284	29.8	1.00				284	23.6	1.00
3-4	173	18.3	1.33	1.01	1.75	.04	173	21.5	1.08	0.81	1.44	.60
5-6	24	11.3	1.77	1.03	3.06		24	19.5	1.17	0.65	2.08
Rb
0-2	97	23.6	1.00				96	22.4	1.00
3-4	347	27.4	0.93	0.62	1.40	.74	347	28.0	0.89	0.58	1.35	.58
5-6	3	31.7	0.87	0.38	1.97		3	35.1	0.79	0.34	1.83
PAI-1
0-2	192	20.8	1.00				191	17.3	1.00
3-4	277	22.2	0.89	0.65	1.23	.49	277	26.0	0.72	0.51	1.02	.06
5-6	8	23.6	0.80	0.42	1.50		8	39.2	0.52	0.26	1.03

¹Univariate analyses are unadjusted. Multivariate analyses are adjusted for age, sex, tumor grade, tumor stage, and lymph nodes.

²Median is the median years progression free as estimated from a parametric model.

³HR is the hazard ratio from a semiparametric (Cox proportional hazards) model. The 95% confidence limits (LCL and UCL) are shown.

⁴The expression p-values are for trend.