Table 1.
Clinical reported 42 cases of G. sanguinis infections.
| Reference | Country | Age | Gender | Underlying conditions | Presenting signs and symptoms | Site of isolation | Infection | Identification | Antibiotic treatment | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|
| [2] | France | 56 | F | N/A | meningitis | CSF | meningitis | 16S rRNA sequencing | CTX, FOM | alive |
| [3] | USA | N/A | F | N/A | N/A | blood | bacteremia | Rapid ID 32 Strep + BBL Crystal Rapid Gram-Positive ID kit + BBL Crystal Gram-Positive ID kit + RapID STR | N/A | N/A |
| [3] | USA | N/A | F | N/A | N/A | blood | bacteremia | same as above | N/A | N/A |
| [3] | USA | N/A | M | N/A | N/A | urine | urinary | same as above | N/A | N/A |
| [3] | USA | N/A | N/A | N/A | N/A | blood | bacteremia | same as above | N/A | N/A |
| [3] | USA | N/A | N/A | N/A | N/A | blood | N/A | same as above | N/A | N/A |
| [3] | USA | 69 | M | N/A | N/A | urine | urinary | same as above | N/A | N/A |
| [3] | USA | 85 | F | N/A | N/A | urine | urinary | same as above | N/A | N/A |
| [3] | USA | N/A | N/A | N/A | N/A | blood | N/A | same as above | N/A | N/A |
| [3] | USA | 1 | M | N/A | N/A | CSF | meningitis | same as above | N/A | N/A |
| [3] | USA | 84 | F | N/A | N/A | blood | sepsis | same as above | N/A | N/A |
| [3] | canada | N/A | F | N/A | N/A | urine | N/A | same as above | N/A | N/A |
| [3] | USA | 90 | F | N/A | N/A | blood | urosepsis | same as above | N/A | N/A |
| [3] | USA | 68 | F | N/A | N/A | blood | N/A | same as above | N/A | N/A |
| [3] | canada | 82 | F | N/A | N/A | blood | N/A | same as above | N/A | N/A |
| [3] | canada | 79 | F | N/A | N/A | blood | N/A | same as above | N/A | N/A |
| [3] | USA | N/A | N/A | N/A | N/A | blood | N/A | same as above | N/A | N/A |
| [3] | USA | 1 | M | N/A | N/A | blood | septocemia | same as above | N/A | N/A |
| [3] | USA | N/A | N/A | N/A | N/A | blood | N/A | same as above | N/A | N/A |
| [3] | USA | 58 | M | N/A | N/A | blood | septocemia | same as above | N/A | N/A |
| [3] | USA | 82 | F | N/A | N/A | blood | septocemia | same as above | N/A | N/A |
| [3] | canada | 2 | F | N/A | N/A | blood | N/A | same as above | N/A | N/A |
| [3] | canada | 92 | F | N/A | N/A | blood | N/A | same as above | N/A | N/A |
| [3] | canada | N/A | F | N/A | N/A | blood | N/A | same as above | N/A | N/A |
| [3] | USA | 70 | F | N/A | N/A | blood | endocarditis | same as above | N/A | N/A |
| [3] | canada | 43 | F | N/A | N/A | CSF | N/A | same as above | N/A | N/A |
| [3] | canada | 85 | M | N/A | N/A | blood | N/A | same as above | N/A | N/A |
| [3] | canada | 1 | F | N/A | N/A | blood | N/A | same as above | N/A | N/A |
| [3] | USA | 3 | F | N/A | N/A | blood | septicemia | same as above | N/A | N/A |
| [4] | Japan | 80 | F | colon cancer, brain stroke,dementia, HTN | fever, pyuria | urine | urinary | 16S rRNA sequencing | ABPC | alive |
| [5] | Korea | 85 | F | parkinson's disease, asthma, hypertwnsion, staying at nursing home | pain and swelling of left arm, fever | blood | bacteremia | partial 16S rRNA sequencing | VCM + CTRX | alive |
| [7] | USA | 72 | F | obesity, gastrip lap banding, tabacco | Hip pain | Hip synovium | prosthetic joint infection | API 20TREP + Vitek 2 g-Positive ID card + MALDI-TOF MS | VCM | alive |
| [7] | USA | 54 | F | obesity, DM, gastric bypass, tabacco | fatigue and fever | blood | bacteremia | MALDI-TOF MS | LZD | alive |
| [12] | Taiwan | 80 | F | chronic diarrhea, DM | cardiac arrest | blood | bacteremia | 16S rRNA sequencing | N/A | died |
| [12] | Taiwan | 92 | F | dementia, CHF | fever, cough | blood | urosepsis | 16S rRNA sequencing | CXM = > CAZ | alive |
| [13] | Denmark | 23 | F | intravenous drug use. Right-sided endocarditis, hepatitis C | pneumonia | blood | bacteremia | Rapid ID32 Strep, partial 16S rRNA sequencing | CXM = > PC | alive |
| [13] | Denmark | 82 | F | alzheimer's disease, hypertension | dehydration | blood | urosepsis | Rapid ID32 Strep, partial 16S rRNA sequencing | PC | alive |
| [13] | Denmark | 56 | M | crohn's disease, atrial fibrillation | erysipelas, dyspnoea, fever | blood | bacteremia | Rapid ID32 Strep, partial 16S rRNA sequencing | CXM | alive |
| [14] | Japan | 94 | M | dementia, CHF, nephrolithiasis | back pain, fever | blood | bacteremia | 16S rRNA sequencing | ABPC/SBT = > VCM | alive |
| [15] | Germany | 69 | F | VPS | meningitis | CSF | meningitis | Rapid ID32 Strep, phoenix PMIC/ID-56 | CTRX | alive |
| [16] | India | 70 | M | Craniectomy | meningitis | CSF | meningitis | Vitek 2 ID | LVFX, CPZ, SBT, AMK = > VCM, LVFX | alive |
DM, diabetes mellitus; CHF, chronic heart failure; VPS, ventriculoperitoneal shunt; CSF, cerebrospinal fluid; VCM, vancomycin; CTRX, ceftriaxone; LZD, linezolid; CXM, cefuroxime; CAZ, ceftazidime; PC, penicillin; ABPC/SBT, ampicillin/sulbactam; ABPC,levofloxacin ampicillin; CTX, cefotaxime; FOM, fosfomycin; LVFX, levofloxacin; CPZ, cefoperazone; SBT, sulbactam; AMK,amikacin; MEPM, meropenem