Crystal structure of N-[6-amino-5-(benzo[d]thia­zol-2-yl)-3-cyano-4-methyl­sulfanyl-2-oxo-1,2-di­hydro­pyridin-1-yl]-4-methyl­benzene­sulfonamide di­methyl­formamide monosolvate

Rasha A Azzam; Galal H Elgemeie; Rasha E Elsayed; Peter G Jones

doi:10.1107/S2056989017015778

. 2017 Nov 3;73(Pt 12):1820–1822. doi: 10.1107/S2056989017015778

Crystal structure of N-[6-amino-5-(benzo[d]thiazol-2-yl)-3-cyano-4-methylsulfanyl-2-oxo-1,2-dihydropyridin-1-yl]-4-methylbenzenesulfonamide dimethylformamide monosolvate

Rasha A Azzam ^a, Galal H Elgemeie ^a, Rasha E Elsayed ^a, Peter G Jones ^b,^*

PMCID: PMC5730231 PMID: 29250394

In the title compound, the toluenesulfonamide ring and the combined ring system involving the pyridone and benzothiazole rings subtend an interplanar angle of 39.86 (4)°. The pyridone and benzothiazyl rings are linked by an intramolecular N—H_amine⋯N_thiazole hydrogen bond. The molecules are linked by hydrogen bonds and an S⋯O contact to form layers parallel to the bc plane.

Keywords: crystal structure, 2-pyridone, benzothiazole, dimethylformamide

Abstract

In the title compound, C₂₁H₁₇N₅O₃S₃·C₃H₇NO, the toluenesulfonamide ring and the combined ring system involving the pyridone and benzothiazole rings subtend an interplanar angle of 39.86 (4)°. The pyridone and benzothiazyl rings are linked by the intramolecular hydrogen bond N—H_amine⋯N_thiazole. The DMF O atom accepts two classical hydrogen bonds. The molecules are linked by hydrogen bonds and an S⋯O contact to form layers parallel to the bc plane.

Chemical context

Cyanoketene dithioacetals are versatile synthetic intermediates (Elgemeie et al., 2003a ▸, 2015 ▸) that have been utilized as building blocks for the synthesis of a wide range of heterocyclic compounds (Elgemeie et al., 2009 ▸, 2017a ▸); they are also of general interest in pharmaceutical chemistry (Elgemeie & Abou-Zeid, 2015 ▸; Elgemeie et al., 2016 ▸). Recently, we have described the synthesis of various antimetabolites starting from cyanoketene dithioacetals and related compounds, viz. cyanoketene S,S-acetals (Elgemeie, Mohamed, 2006 ▸), cyanoketene N,S-acetals (Elgemeie et al. 2017b ▸), and cyanoketene N,N-acetals (Elgemeie et al., 2003b ▸). As a part of this programme, the reaction of 2-(benzo[d]thiazol-2-yl)-3,3-bis(methylthio)acrylonitrile (1) with N-(2-cyanoacetyl)-4-methylbenzenesulfonohydrazide (2) was investigated. The reaction between 1 and 2 in KOH–DMF gives an adduct for which four possible isomeric structures were considered (structures 3–6). Spectroscopic methods did not allow us to identify the product unambiguously and therefore the X-ray crystal structure was determined, confirming the exclusive presence of structure 6 in the solid state. The formation of 6 from the reaction of 1 and 2 is assumed to proceed via initial addition of the active methylene carbon atom of 2 to the double bond of 1, followed by elimination of CH₃SH and cyclization via addition of the NH group to the cyano group of benzothiazole to give the favoured, kinetically and thermodynamically controlled product 6. The ¹H NMR spectra of the product revealed the presence of an amino group at δ = 8.84 p.p.m. and a pyridine methylthio group at δ = 2.45 p.p.m. in solution. Compound 6 and its derivatives showed interesting preclinical biological results and are currently being patented (Elgemeie et al., 2017c ▸).

Structural commentary

The solid-state structure of 6 is shown in Fig. 1 ▸, the structure analysis thereby confirming the nature of the product. The molecule essentially consists of two planes; the toluenesulfonamide ring and the combined ring system involving the pyridone and benzothiazole rings. The former has a r.m.s. deviation of 0.04 Å and the latter of 0.01 Å (including all direct substituents), and the interplanar angle is 39.86 (4)°. The pyridone and benzothiazyl rings are held coplanar by the intramolecular hydrogen bond N4—H03⋯N3 (Table 1 ▸). The contact N4—H02⋯N1 might also be classified as a hydrogen bond, with H⋯N 2.24 (2) Å, but its angle is only 105.7 (15)°. The nitrogen N4 is planar (angle sum 359.7°) but N1 is pyramidalized (343.9°).

The structure of the title compound in the crystal. Displacement ellipsoids represent 50% probability levels.

Table 1. Hydrogen-bond geometry (Å, °).

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N1—H01⋯O99ⁱ	0.888 (18)	1.872 (18)	2.7583 (13)	175.7 (16)
N4—H02⋯O99	0.84 (2)	2.05 (2)	2.8334 (14)	154.6 (18)
N4—H03⋯N3	0.86 (2)	1.86 (2)	2.5760 (15)	139.9 (17)
N4—H02⋯N1	0.84 (2)	2.237 (19)	2.5932 (14)	105.7 (15)
C7—H7⋯O3ⁱⁱ	0.95	2.54	3.3161 (16)	139
C20—H20⋯O2ⁱⁱⁱ	0.95	2.64	3.5605 (16)	164
C97—H97C⋯N5^iv	0.98	2.59	3.504 (2)	155

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Symmetry codes: (i) Inline graphic ; (ii) ; (iii) ; (iv) .

Supramolecular features

The oyxgen atom of the dimethylformamide accepts two classical hydrogen bonds. The clearest packing feature is the formation of layers parallel to the bc plane (Fig. 2 ▸), in which the hydrogen bonds H02⋯O99, H7⋯O3ⁱⁱ and H97C⋯N5^iv are involved (Table 1 ▸), together with the short contact S1⋯O3(x, 1 + y, z) 3.2662 (10) Å. The hydrogen bond H01⋯O99ⁱ connects the layers in the third dimension.

Packing diagram of the title compound viewed perpendicular to the bc plane. Dashed lines indicate classical hydrogen bonds (thick) or C—H⋯X and S⋯O interactions (thin).

Database survey

The 2-pyridone ring displays the usual features of a narrow angle at nitrogen and a wide angle at the carbonyl carbon (Table 2 ▸). A database search gave 555 hits (745 values) for the 2-pyridone ring, with average angles of 123.9° at nitrogen and 115.3° at C=O. No other structures could be found in which a 2-pyridone ring is attached at the 5-position to the C2 atom of a thiazol ring.

Table 2. Selected bond angles (°).

N2—C11—C10

113.44 (10)

C12—N2—C11

125.63 (10)

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Synthesis and crystallization

2-(Benzo[d]thiazol-2-yl)-3,3-bis(methylthio)acrylonitrile (1) (2.78 g, 0.01 mol) was added to a solution of N-(2-cyanoacetyl)-4-methylbenzenesulfonohydrazide (2) (2.53 g., 0.01 mol) in dry DMF (30 ml) containing pulverized potassium hydroxide (0.56 g, 0.01 mol). The reaction mixture was refluxed with stirring for 2 h (TLC monitoring). After cooling, the reaction mixture was poured into ice-cold water and neutralized with HCl. The solid product was filtered off, washed with water, and dried. It was further purified from hot ethyl acetate: petroleum ether (1:1). The precipitated solid was crystallized from DMF to give yellow crystals, m.p. = 494 K, yield 78%.

IR (KBr, cm⁻¹): ν 3393, 3208 (NH, NH₂), 3072 (ArCH), 2922 (CH₃), 2210 (CN), 1677 (CO), 1594 (C=N), 1350, 1170 (O=S=O); ¹H NMR (400 MHz, DMSO-d ₆): δ 2.42 (s, 3H, CH₃), 2.45 (s, 3H, SCH₃), 7.42 (d, J = 8 Hz, 2H, C₆H₄), 7.49 (t, J = 8 Hz, 1H, benzothiazole H), 7.56 (t, J = 8 Hz, 1H, benzothiazole H), 7.71 (d, J = 8 Hz, 2H, C₆H₄), 8.06 (d, J = 8 Hz, 1H, benzothiazole H), 8.13 (d, J = 8 Hz, 1H, benzothiazole H), 8.84 (br, 2H, NH₂), 11.44 (s, 1H, NH). Analysis calculated for C₂₁H₁₇N₅O₃S₃ (483.59): C 52.16, H 3.54, N 14.48%; found: C 52.11; H 3.48; N 14.50%; MS m/z (%): 484 (M+1, 1.03%), 384 (84%), 356 (100%), 283 (60%), 117 (77%).

Refinement

Crystal data, data collection and structure refinement details are summarized in Table 3 ▸. NH hydrogen atoms were refined freely. Methyl hydrogen atoms were refined as idealized rigid groups allowed to rotate but not tip (AFIX 137), with C—H 0.98 Å and H—C—H 109.5°. Other hydrogen atoms were included using a riding model starting from calculated positions (C—H_aromatic 0.95, C—H_methine 1.00 Å) with U _iso(H) = 1.5U _eq(C) for methyl H atoms and 1.2U _eq(C) for all others.

Table 3. Experimental details.

Crystal data
Chemical formula	C₂₁H₁₇N₅O₃S₃·C₃H₇NO
M _r	556.67
Crystal system, space group	Triclinic, P
Temperature (K)	100
a, b, c (Å)	9.9916 (5), 11.7805 (6), 11.9776 (6)
α, β, γ (°)	88.809 (4), 79.159 (4), 67.245 (5)
V (Å³)	1274.80 (12)
Z	2
Radiation type	Mo Kα
μ (mm⁻¹)	0.34
Crystal size (mm)	0.5 × 0.4 × 0.2

Data collection
Diffractometer	Oxford Diffraction Xcalibur Eos
Absorption correction	Multi-scan (CrysAlis PRO; Rigaku OD, 2015 ▸)
T _min, T _max	0.972, 1.000
No. of measured, independent and observed [I > 2σ(I)] reflections	68326, 7630, 6682
R _int	0.036
(sin θ/λ)_max (Å⁻¹)	0.726

Refinement
R[F ² > 2σ(F ²)], wR(F ²), S	0.033, 0.082, 1.04
No. of reflections	7630
No. of parameters	350
H-atom treatment	H atoms treated by a mixture of independent and constrained refinement
Δρ_max, Δρ_min (e Å⁻³)	0.61, −0.36

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Computer programs: CrysAlis PRO (Rigaku OD, 2015 ▸), SHELXS97 and SHELXL97 (Sheldrick, 2008 ▸), SHELXL2017 (Sheldrick, 2015 ▸) and XP (Siemens, 1994 ▸).

Supplementary Material

Crystal structure: contains datablock(s) I, global. DOI: 10.1107/S2056989017015778/hg5500sup1.cif

e-73-01820-sup1.cif^{(1.9MB, cif)}

Structure factors: contains datablock(s) I. DOI: 10.1107/S2056989017015778/hg5500Isup2.hkl

e-73-01820-Isup2.hkl^{(605.9KB, hkl)}

CCDC reference: 1582798

Additional supporting information: crystallographic information; 3D view; checkCIF report

supplementary crystallographic information

Crystal data

C₂₁H₁₇N₅O₃S₃·C₃H₇NO	Z = 2
M_r = 556.67	F(000) = 580
Triclinic, P1	D_x = 1.450 Mg m⁻³
a = 9.9916 (5) Å	Mo Kα radiation, λ = 0.71073 Å
b = 11.7805 (6) Å	Cell parameters from 19857 reflections
c = 11.9776 (6) Å	θ = 2.3–30.6°
α = 88.809 (4)°	µ = 0.34 mm⁻¹
β = 79.159 (4)°	T = 100 K
γ = 67.245 (5)°	Tablet, yellow
V = 1274.80 (12) Å³	0.5 × 0.4 × 0.2 mm

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Data collection

Oxford Diffraction Xcalibur Eos diffractometer	7630 independent reflections
Radiation source: fine-focus sealed X-ray tube	6682 reflections with I > 2σ(I)
Detector resolution: 16.1419 pixels mm^-1	R_int = 0.036
ω–scan	θ_max = 31.1°, θ_min = 2.3°
Absorption correction: multi-scan (CrysAlis PRO; Rigaku Oxford Diffraction, 2015)	h = −14→14
T_min = 0.972, T_max = 1.000	k = −16→16
68326 measured reflections	l = −17→17

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Refinement

Refinement on F²	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F² > 2σ(F²)] = 0.033	Hydrogen site location: mixed
wR(F²) = 0.082	H atoms treated by a mixture of independent and constrained refinement
S = 1.04	w = 1/[σ²(F_o²) + (0.0337P)² + 0.772P] where P = (F_o² + 2F_c²)/3
7630 reflections	(Δ/σ)_max = 0.001
350 parameters	Δρ_max = 0.61 e Å⁻³
0 restraints	Δρ_min = −0.36 e Å⁻³

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Special details

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

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Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²)

	x	y	z	U_iso*/U_eq
S1	0.20917 (3)	1.05419 (3)	0.44384 (2)	0.01311 (6)
C2	0.17424 (12)	0.91906 (10)	0.43367 (10)	0.0117 (2)
N3	0.13892 (11)	0.90316 (9)	0.33646 (8)	0.01298 (18)
C3A	0.13978 (12)	0.99549 (11)	0.26319 (10)	0.0130 (2)
C4	0.10933 (14)	1.00118 (12)	0.15352 (10)	0.0165 (2)
H4	0.086143	0.938809	0.122941	0.020*
C5	0.11382 (14)	1.10006 (12)	0.09052 (11)	0.0183 (2)
H5	0.094063	1.105310	0.015622	0.022*
C6	0.14719 (14)	1.19255 (12)	0.13597 (11)	0.0185 (2)
H6	0.148137	1.260042	0.091474	0.022*
C7	0.17885 (14)	1.18784 (11)	0.24436 (11)	0.0167 (2)
H7	0.201612	1.250566	0.274740	0.020*
C7A	0.17590 (13)	1.08692 (11)	0.30715 (10)	0.0134 (2)
C8	0.18455 (12)	0.82947 (10)	0.52233 (10)	0.0113 (2)
C9	0.21641 (12)	0.84103 (10)	0.63037 (10)	0.0119 (2)
C10	0.22112 (13)	0.75420 (11)	0.71150 (10)	0.0130 (2)
C11	0.19296 (13)	0.64662 (11)	0.69151 (10)	0.0126 (2)
C12	0.16105 (12)	0.72035 (10)	0.49822 (9)	0.0112 (2)
C13	0.25168 (14)	0.76681 (11)	0.82143 (11)	0.0161 (2)
C14	0.44732 (16)	0.90452 (15)	0.64337 (18)	0.0375 (4)
H14A	0.482909	0.832100	0.688175	0.056*
H14B	0.484276	0.965711	0.663453	0.056*
H14C	0.483227	0.879848	0.562098	0.056*
S2	0.28523 (3)	0.39958 (3)	0.51130 (2)	0.01363 (7)
S3	0.24867 (3)	0.97028 (3)	0.67335 (3)	0.01445 (7)
O1	0.18556 (10)	0.56948 (8)	0.75942 (7)	0.01650 (17)
O2	0.39814 (10)	0.43053 (8)	0.44172 (8)	0.01993 (19)
O3	0.22015 (11)	0.32617 (8)	0.46616 (8)	0.01989 (19)
N1	0.14142 (11)	0.53246 (9)	0.55209 (8)	0.01215 (18)
H01	0.0686 (19)	0.5236 (16)	0.6018 (15)	0.024 (4)*
N2	0.17243 (11)	0.63362 (9)	0.57965 (8)	0.01120 (18)
N4	0.13014 (12)	0.69607 (10)	0.40197 (9)	0.01497 (19)
H02	0.116 (2)	0.6318 (18)	0.3914 (16)	0.031 (5)*
H03	0.118 (2)	0.7536 (18)	0.3545 (16)	0.030 (5)*
N5	0.27764 (14)	0.77140 (11)	0.91037 (10)	0.0249 (2)
C15	0.35093 (13)	0.32693 (11)	0.63125 (10)	0.0142 (2)
C16	0.27838 (14)	0.25780 (11)	0.69169 (11)	0.0162 (2)
H16	0.196647	0.250018	0.667958	0.019*
C17	0.32777 (14)	0.20066 (11)	0.78708 (11)	0.0174 (2)
H17	0.278268	0.154275	0.829314	0.021*
C18	0.44894 (14)	0.21006 (11)	0.82216 (11)	0.0173 (2)
C19	0.51825 (14)	0.28051 (12)	0.76017 (11)	0.0184 (2)
H19	0.600293	0.288172	0.783499	0.022*
C20	0.46997 (13)	0.33974 (11)	0.66507 (11)	0.0168 (2)
H20	0.517566	0.388092	0.623997	0.020*
C21	0.50385 (16)	0.14328 (14)	0.92318 (12)	0.0247 (3)
H21A	0.419338	0.152364	0.984240	0.037*
H21B	0.567230	0.178318	0.950152	0.037*
H21C	0.560779	0.055639	0.901004	0.037*
C97	0.20835 (19)	0.51005 (15)	−0.00331 (12)	0.0303 (3)
H97A	0.105803	0.547512	−0.014305	0.045*
H97B	0.258431	0.429728	−0.045575	0.045*
H97C	0.259893	0.563981	−0.031259	0.045*
C98	0.35300 (17)	0.44892 (18)	0.15100 (14)	0.0356 (4)
H98A	0.339323	0.441322	0.233601	0.053*
H98B	0.400502	0.507200	0.129860	0.053*
H98C	0.415656	0.368141	0.112343	0.053*
C99	0.08612 (15)	0.51648 (12)	0.19300 (11)	0.0186 (2)
H99	−0.003677	0.541604	0.165524	0.022*
N99	0.20970 (13)	0.49363 (11)	0.11715 (9)	0.0198 (2)
O99	0.07862 (10)	0.50763 (9)	0.29665 (7)	0.01853 (18)

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Atomic displacement parameters (Å²)

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
S1	0.01528 (13)	0.01090 (13)	0.01511 (13)	−0.00706 (10)	−0.00348 (10)	0.00176 (10)
C2	0.0104 (5)	0.0097 (5)	0.0145 (5)	−0.0042 (4)	−0.0008 (4)	0.0002 (4)
N3	0.0147 (4)	0.0121 (4)	0.0126 (4)	−0.0060 (4)	−0.0022 (3)	0.0015 (3)
C3A	0.0114 (5)	0.0121 (5)	0.0137 (5)	−0.0038 (4)	−0.0004 (4)	0.0013 (4)
C4	0.0173 (5)	0.0168 (5)	0.0156 (5)	−0.0069 (4)	−0.0032 (4)	0.0016 (4)
C5	0.0184 (6)	0.0200 (6)	0.0148 (5)	−0.0059 (5)	−0.0029 (4)	0.0046 (4)
C6	0.0188 (6)	0.0156 (6)	0.0195 (6)	−0.0062 (5)	−0.0020 (5)	0.0059 (4)
C7	0.0174 (5)	0.0130 (5)	0.0198 (6)	−0.0067 (4)	−0.0021 (4)	0.0038 (4)
C7A	0.0124 (5)	0.0122 (5)	0.0143 (5)	−0.0042 (4)	−0.0013 (4)	0.0020 (4)
C8	0.0114 (5)	0.0092 (5)	0.0130 (5)	−0.0041 (4)	−0.0016 (4)	−0.0003 (4)
C9	0.0108 (5)	0.0108 (5)	0.0139 (5)	−0.0041 (4)	−0.0017 (4)	−0.0015 (4)
C10	0.0140 (5)	0.0127 (5)	0.0123 (5)	−0.0049 (4)	−0.0032 (4)	−0.0008 (4)
C11	0.0133 (5)	0.0126 (5)	0.0108 (5)	−0.0039 (4)	−0.0023 (4)	−0.0005 (4)
C12	0.0115 (5)	0.0105 (5)	0.0113 (5)	−0.0044 (4)	−0.0007 (4)	0.0004 (4)
C13	0.0178 (5)	0.0139 (5)	0.0172 (6)	−0.0060 (4)	−0.0053 (4)	0.0001 (4)
C14	0.0149 (6)	0.0276 (8)	0.0685 (12)	−0.0089 (6)	−0.0016 (7)	−0.0143 (8)
S2	0.01854 (14)	0.00982 (12)	0.01155 (13)	−0.00509 (10)	−0.00151 (10)	−0.00011 (9)
S3	0.01584 (13)	0.01206 (13)	0.01707 (14)	−0.00662 (10)	−0.00418 (10)	−0.00170 (10)
O1	0.0234 (4)	0.0140 (4)	0.0126 (4)	−0.0076 (3)	−0.0040 (3)	0.0024 (3)
O2	0.0211 (4)	0.0179 (4)	0.0164 (4)	−0.0061 (4)	0.0033 (3)	0.0016 (3)
O3	0.0315 (5)	0.0121 (4)	0.0181 (4)	−0.0088 (4)	−0.0089 (4)	−0.0005 (3)
N1	0.0155 (5)	0.0092 (4)	0.0131 (4)	−0.0067 (4)	−0.0018 (4)	0.0001 (3)
N2	0.0153 (4)	0.0090 (4)	0.0108 (4)	−0.0063 (3)	−0.0028 (3)	0.0000 (3)
N4	0.0237 (5)	0.0127 (5)	0.0129 (5)	−0.0107 (4)	−0.0062 (4)	0.0025 (4)
N5	0.0317 (6)	0.0252 (6)	0.0212 (6)	−0.0117 (5)	−0.0121 (5)	0.0009 (5)
C15	0.0168 (5)	0.0100 (5)	0.0139 (5)	−0.0038 (4)	−0.0017 (4)	0.0002 (4)
C16	0.0190 (6)	0.0137 (5)	0.0177 (6)	−0.0080 (4)	−0.0046 (4)	0.0019 (4)
C17	0.0210 (6)	0.0139 (5)	0.0172 (6)	−0.0073 (5)	−0.0030 (4)	0.0025 (4)
C18	0.0171 (5)	0.0147 (5)	0.0152 (5)	−0.0013 (4)	−0.0026 (4)	−0.0005 (4)
C19	0.0130 (5)	0.0194 (6)	0.0208 (6)	−0.0040 (4)	−0.0030 (4)	−0.0009 (5)
C20	0.0145 (5)	0.0151 (5)	0.0190 (6)	−0.0054 (4)	0.0001 (4)	−0.0003 (4)
C21	0.0214 (6)	0.0284 (7)	0.0198 (6)	−0.0041 (5)	−0.0063 (5)	0.0065 (5)
C97	0.0417 (9)	0.0361 (8)	0.0130 (6)	−0.0163 (7)	−0.0027 (6)	0.0032 (5)
C98	0.0233 (7)	0.0561 (11)	0.0247 (7)	−0.0136 (7)	−0.0018 (6)	−0.0001 (7)
C99	0.0228 (6)	0.0182 (6)	0.0164 (6)	−0.0094 (5)	−0.0045 (5)	0.0006 (4)
N99	0.0238 (5)	0.0229 (5)	0.0126 (5)	−0.0098 (4)	−0.0021 (4)	0.0011 (4)
O99	0.0248 (5)	0.0228 (5)	0.0127 (4)	−0.0153 (4)	−0.0016 (3)	−0.0004 (3)

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Geometric parameters (Å, º)

S1—C7A	1.7375 (12)	S2—N1	1.6678 (10)
S1—C2	1.7677 (12)	S2—C15	1.7597 (12)
C2—N3	1.3153 (15)	N1—N2	1.4020 (13)
C2—C8	1.4706 (15)	N1—H01	0.888 (18)
N3—C3A	1.3848 (14)	N4—H02	0.84 (2)
C3A—C4	1.3977 (17)	N4—H03	0.86 (2)
C3A—C7A	1.4013 (17)	C15—C20	1.3872 (17)
C4—C5	1.3855 (17)	C15—C16	1.3955 (17)
C4—H4	0.9500	C16—C17	1.3875 (17)
C5—C6	1.4031 (19)	C16—H16	0.9500
C5—H5	0.9500	C17—C18	1.3970 (18)
C6—C7	1.3880 (18)	C17—H17	0.9500
C6—H6	0.9500	C18—C19	1.3948 (18)
C7—C7A	1.4005 (16)	C18—C21	1.5034 (18)
C7—H7	0.9500	C19—C20	1.3894 (18)
C8—C9	1.4108 (16)	C19—H19	0.9500
C8—C12	1.4372 (15)	C20—H20	0.9500
C9—C10	1.3897 (16)	C21—H21A	0.9800
C9—S3	1.7781 (12)	C21—H21B	0.9800
C10—C13	1.4295 (16)	C21—H21C	0.9800
C10—C11	1.4340 (16)	C97—N99	1.4536 (17)
C11—O1	1.2213 (14)	C97—H97A	0.9800
C11—N2	1.4132 (14)	C97—H97B	0.9800
C12—N4	1.3124 (15)	C97—H97C	0.9800
C12—N2	1.3851 (14)	C98—N99	1.4554 (19)
C13—N5	1.1499 (17)	C98—H98A	0.9800
C14—S3	1.7952 (15)	C98—H98B	0.9800
C14—H14A	0.9800	C98—H98C	0.9800
C14—H14B	0.9800	C99—O99	1.2343 (15)
C14—H14C	0.9800	C99—N99	1.3242 (17)
S2—O3	1.4317 (10)	C99—H99	0.9500
S2—O2	1.4326 (9)

C7A—S1—C2	89.58 (6)	N2—N1—S2	117.20 (8)
N3—C2—C8	121.49 (10)	N2—N1—H01	113.6 (11)
N3—C2—S1	113.55 (8)	S2—N1—H01	113.1 (11)
C8—C2—S1	124.95 (9)	C12—N2—N1	115.94 (9)
C2—N3—C3A	112.58 (10)	C12—N2—C11	125.63 (10)
N3—C3A—C4	125.08 (11)	N1—N2—C11	117.88 (9)
N3—C3A—C7A	114.40 (10)	C12—N4—H02	121.2 (13)
C4—C3A—C7A	120.52 (11)	C12—N4—H03	114.9 (13)
C5—C4—C3A	118.33 (12)	H02—N4—H03	123.6 (18)
C5—C4—H4	120.8	C20—C15—C16	121.33 (11)
C3A—C4—H4	120.8	C20—C15—S2	120.72 (9)
C4—C5—C6	120.82 (12)	C16—C15—S2	117.94 (9)
C4—C5—H5	119.6	C17—C16—C15	118.80 (12)
C6—C5—H5	119.6	C17—C16—H16	120.6
C7—C6—C5	121.60 (11)	C15—C16—H16	120.6
C7—C6—H6	119.2	C16—C17—C18	121.22 (12)
C5—C6—H6	119.2	C16—C17—H17	119.4
C6—C7—C7A	117.34 (12)	C18—C17—H17	119.4
C6—C7—H7	121.3	C19—C18—C17	118.44 (11)
C7A—C7—H7	121.3	C19—C18—C21	121.38 (12)
C7—C7A—C3A	121.37 (11)	C17—C18—C21	120.17 (12)
C7—C7A—S1	128.74 (10)	C20—C19—C18	121.46 (12)
C3A—C7A—S1	109.88 (8)	C20—C19—H19	119.3
C9—C8—C12	116.48 (10)	C18—C19—H19	119.3
C9—C8—C2	125.41 (10)	C15—C20—C19	118.73 (11)
C12—C8—C2	118.11 (10)	C15—C20—H20	120.6
C10—C9—C8	122.53 (10)	C19—C20—H20	120.6
C10—C9—S3	115.37 (9)	C18—C21—H21A	109.5
C8—C9—S3	122.08 (9)	C18—C21—H21B	109.5
C9—C10—C13	122.46 (11)	H21A—C21—H21B	109.5
C9—C10—C11	122.30 (10)	C18—C21—H21C	109.5
C13—C10—C11	115.24 (10)	H21A—C21—H21C	109.5
O1—C11—N2	119.46 (11)	H21B—C21—H21C	109.5
O1—C11—C10	127.10 (11)	N99—C97—H97A	109.5
N2—C11—C10	113.44 (10)	N99—C97—H97B	109.5
N4—C12—N2	116.83 (10)	H97A—C97—H97B	109.5
N4—C12—C8	123.94 (11)	N99—C97—H97C	109.5
N2—C12—C8	119.23 (10)	H97A—C97—H97C	109.5
N5—C13—C10	176.92 (13)	H97B—C97—H97C	109.5
S3—C14—H14A	109.5	N99—C98—H98A	109.5
S3—C14—H14B	109.5	N99—C98—H98B	109.5
H14A—C14—H14B	109.5	H98A—C98—H98B	109.5
S3—C14—H14C	109.5	N99—C98—H98C	109.5
H14A—C14—H14C	109.5	H98A—C98—H98C	109.5
H14B—C14—H14C	109.5	H98B—C98—H98C	109.5
O3—S2—O2	121.42 (6)	O99—C99—N99	125.03 (13)
O3—S2—N1	102.99 (5)	O99—C99—H99	117.5
O2—S2—N1	106.32 (5)	N99—C99—H99	117.5
O3—S2—C15	106.76 (6)	C99—N99—C97	121.56 (12)
O2—S2—C15	109.03 (6)	C99—N99—C98	121.18 (12)
N1—S2—C15	109.88 (5)	C97—N99—C98	117.25 (12)
C9—S3—C14	98.98 (6)

C7A—S1—C2—N3	−0.89 (9)	C2—C8—C12—N4	−0.37 (17)
C7A—S1—C2—C8	178.19 (10)	C9—C8—C12—N2	−0.79 (15)
C8—C2—N3—C3A	−178.06 (10)	C2—C8—C12—N2	179.01 (10)
S1—C2—N3—C3A	1.06 (13)	C10—C9—S3—C14	83.40 (11)
C2—N3—C3A—C4	178.78 (11)	C8—C9—S3—C14	−98.15 (12)
C2—N3—C3A—C7A	−0.70 (14)	O3—S2—N1—N2	−167.59 (8)
N3—C3A—C4—C5	179.67 (11)	O2—S2—N1—N2	−38.90 (9)
C7A—C3A—C4—C5	−0.89 (17)	C15—S2—N1—N2	78.95 (9)
C3A—C4—C5—C6	−0.39 (18)	N4—C12—N2—N1	−3.39 (15)
C4—C5—C6—C7	0.93 (19)	C8—C12—N2—N1	177.19 (10)
C5—C6—C7—C7A	−0.15 (18)	N4—C12—N2—C11	−174.61 (10)
C6—C7—C7A—C3A	−1.15 (17)	C8—C12—N2—C11	5.97 (17)
C6—C7—C7A—S1	−179.72 (9)	S2—N1—N2—C12	103.12 (10)
N3—C3A—C7A—C7	−178.80 (11)	S2—N1—N2—C11	−84.95 (11)
C4—C3A—C7A—C7	1.70 (17)	O1—C11—N2—C12	172.21 (11)
N3—C3A—C7A—S1	0.01 (13)	C10—C11—N2—C12	−7.76 (16)
C4—C3A—C7A—S1	−179.49 (9)	O1—C11—N2—N1	1.15 (16)
C2—S1—C7A—C7	179.17 (12)	C10—C11—N2—N1	−178.82 (9)
C2—S1—C7A—C3A	0.47 (9)	O3—S2—C15—C20	152.17 (10)
N3—C2—C8—C9	−177.62 (11)	O2—S2—C15—C20	19.34 (12)
S1—C2—C8—C9	3.36 (16)	N1—S2—C15—C20	−96.82 (10)
N3—C2—C8—C12	2.61 (16)	O3—S2—C15—C16	−28.68 (11)
S1—C2—C8—C12	−176.41 (8)	O2—S2—C15—C16	−161.51 (9)
C12—C8—C9—C10	−1.79 (16)	N1—S2—C15—C16	82.33 (10)
C2—C8—C9—C10	178.44 (11)	C20—C15—C16—C17	−0.33 (18)
C12—C8—C9—S3	179.88 (8)	S2—C15—C16—C17	−179.47 (9)
C2—C8—C9—S3	0.10 (16)	C15—C16—C17—C18	−0.79 (19)
C8—C9—C10—C13	−179.23 (11)	C16—C17—C18—C19	1.19 (18)
S3—C9—C10—C13	−0.79 (15)	C16—C17—C18—C21	−177.66 (12)
C8—C9—C10—C11	−0.40 (18)	C17—C18—C19—C20	−0.49 (19)
S3—C9—C10—C11	178.04 (9)	C21—C18—C19—C20	178.35 (12)
C9—C10—C11—O1	−175.15 (12)	C16—C15—C20—C19	1.01 (18)
C13—C10—C11—O1	3.76 (18)	S2—C15—C20—C19	−179.87 (9)
C9—C10—C11—N2	4.82 (16)	C18—C19—C20—C15	−0.59 (19)
C13—C10—C11—N2	−176.27 (10)	O99—C99—N99—C97	−178.03 (13)
C9—C8—C12—N4	179.84 (11)	O99—C99—N99—C98	3.0 (2)

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Hydrogen-bond geometry (Å, º)

D—H···A	D—H	H···A	D···A	D—H···A
N1—H01···O99ⁱ	0.888 (18)	1.872 (18)	2.7583 (13)	175.7 (16)
N4—H02···O99	0.84 (2)	2.05 (2)	2.8334 (14)	154.6 (18)
N4—H03···N3	0.86 (2)	1.86 (2)	2.5760 (15)	139.9 (17)
N4—H02···N1	0.84 (2)	2.237 (19)	2.5932 (14)	105.7 (15)
C7—H7···O3ⁱⁱ	0.95	2.54	3.3161 (16)	139
C20—H20···O2ⁱⁱⁱ	0.95	2.64	3.5605 (16)	164
C97—H97C···N5^iv	0.98	2.59	3.504 (2)	155

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Symmetry codes: (i) −x, −y+1, −z+1; (ii) x, y+1, z; (iii) −x+1, −y+1, −z+1; (iv) x, y, z−1.

References

Elgemeie, G. H. & Abou-Zeid, M. (2015). Nucleosides Nucleotides Nucleic Acids, 34, 834–847. [DOI] [PubMed]
Elgemeie, G. H., Abou-Zeid, M., Alsaid, S., Hebishy, A. & Essa, H. (2015). Nucleosides Nucleotides Nucleic Acids, 34, 659–673. [DOI] [PubMed]
Elgemeie, G. H., Abou-Zeid, M. & Azzam, R. (2016). Nucleosides Nucleotides Nucleic Acids, 35, 211–222. [DOI] [PubMed]
Elgemeie, G. H., Azzam, R. A. & Elsayed, R. E. (2017c). Patent No. 1554/2017. Egyptian Academy of Scientific Research.
Elgemeie, G. H., El-Ezbawy, S. R. & Sood, S. A. (2003a). Synth. Commun. 33, 2095–2101.
Elgemeie, G. H., Elghandour, A. H. & Abd Elaziz, G. W. (2003b). Synth. Commun. 33, 1659–1664.
Elgemeie, G. H., Elsayed, S. H. & Hassan, A. S. (2009). Synth. Commun. 39, 1781–1792.
Elgemeie, G. H., Fathy, N., Zaghary, W. & Farag, A. (2017b). Nucleosides Nucleotides Nucleic Acids, 36, 198–212. [DOI] [PubMed]
Elgemeie, G. H. & Mohamed, M. A. (2006). Synth. Commun. 36, 1025–1038.
Elgemeie, G. H., Salah, A. M., Abbas, N. S., Hussein, H. A. & Mohamed, R. A. (2017a). Nucleosides Nucleotides Nucleic Acids, 36, 213–223. [DOI] [PubMed]
Rigaku OD (2015). CrysAlis PRO. Rigaku Oxford Diffraction, Abingdon, UK.
Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. [DOI] [PubMed]
Sheldrick, G. M. (2015). Acta Cryst. C71, 3–8.
Siemens (1994). XP. Siemens Analytical X–Ray Instruments, Madison, Wisconsin, Wisconsin USA.

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

Crystal structure: contains datablock(s) I, global. DOI: 10.1107/S2056989017015778/hg5500sup1.cif

e-73-01820-sup1.cif^{(1.9MB, cif)}

Structure factors: contains datablock(s) I. DOI: 10.1107/S2056989017015778/hg5500Isup2.hkl

e-73-01820-Isup2.hkl^{(605.9KB, hkl)}

CCDC reference: 1582798

Additional supporting information: crystallographic information; 3D view; checkCIF report

[bb1] Elgemeie, G. H. & Abou-Zeid, M. (2015). Nucleosides Nucleotides Nucleic Acids, 34, 834–847. [DOI] [PubMed]

[bb2] Elgemeie, G. H., Abou-Zeid, M., Alsaid, S., Hebishy, A. & Essa, H. (2015). Nucleosides Nucleotides Nucleic Acids, 34, 659–673. [DOI] [PubMed]

[bb3] Elgemeie, G. H., Abou-Zeid, M. & Azzam, R. (2016). Nucleosides Nucleotides Nucleic Acids, 35, 211–222. [DOI] [PubMed]

[bb4] Elgemeie, G. H., Azzam, R. A. & Elsayed, R. E. (2017c). Patent No. 1554/2017. Egyptian Academy of Scientific Research.

[bb5] Elgemeie, G. H., El-Ezbawy, S. R. & Sood, S. A. (2003a). Synth. Commun. 33, 2095–2101.

[bb6] Elgemeie, G. H., Elghandour, A. H. & Abd Elaziz, G. W. (2003b). Synth. Commun. 33, 1659–1664.

[bb7] Elgemeie, G. H., Elsayed, S. H. & Hassan, A. S. (2009). Synth. Commun. 39, 1781–1792.

[bb8] Elgemeie, G. H., Fathy, N., Zaghary, W. & Farag, A. (2017b). Nucleosides Nucleotides Nucleic Acids, 36, 198–212. [DOI] [PubMed]

[bb9] Elgemeie, G. H. & Mohamed, M. A. (2006). Synth. Commun. 36, 1025–1038.

[bb10] Elgemeie, G. H., Salah, A. M., Abbas, N. S., Hussein, H. A. & Mohamed, R. A. (2017a). Nucleosides Nucleotides Nucleic Acids, 36, 213–223. [DOI] [PubMed]

[bb11] Rigaku OD (2015). CrysAlis PRO. Rigaku Oxford Diffraction, Abingdon, UK.

[bb12] Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. [DOI] [PubMed]

[bb13] Sheldrick, G. M. (2015). Acta Cryst. C71, 3–8.

[bb14] Siemens (1994). XP. Siemens Analytical X–Ray Instruments, Madison, Wisconsin, Wisconsin USA.

PERMALINK

Crystal structure of N-[6-amino-5-(benzo[d]thiazol-2-yl)-3-cyano-4-methylsulfanyl-2-oxo-1,2-dihydropyridin-1-yl]-4-methylbenzenesulfonamide dimethylformamide monosolvate

Rasha A Azzam

Galal H Elgemeie

Rasha E Elsayed

Peter G Jones

Abstract

Chemical context

Structural commentary