Table 1. A selection of significantly regulated genes in c-Myc-induced lung papillary adenocarcinoma*.
| ACC | Gene Symbol | Gene Title | Fold Change | ||
|---|---|---|---|---|---|
| Size of tumors | |||||
| Small | Middle | Large | |||
| (A) Up-regulated genes in c-Myc induced lung tumors | |||||
| L00039 | Myc | Myelocytomatosis oncogene | 51.0 | 23.4 | 58.6 |
| AI467390 | Map2k1 | Mitogen activated protein kinase kinase 1 | 2.7 | 2.7 | 3.6 |
| U15443 | Ros1 | Ros1 proto-oncogene | 9.3 | 13.3 | 21.9 |
| AV109962 | Traf4 | Tnf receptor associated factor 4 | 4.3 | 5.0 | 4.5 |
| X63099 | Gjb3 | Gap junction membrane channel protein beta 3 | 8.7 | 7.5 | 8.8 |
| M22832 | Krt18 | Keratin complex 1. acidic. gene 18 | 2.9 | 3.2 | 3.6 |
| AF011450 | Col15a1 | Procollagen. type XV | 1.7 | 5.1 | 4.6 |
| AA170696 | Icam1 | Intercellular adhesion molecule | 3.3 | 1.8 | 2.8 |
| AW228162 | Dsc2 | Desmocollin 2 | 4.1 | 4.1 | 4.4 |
| X81627 | Lcn2 | Lipocalin 2 | 4.8 | 7.3 | 4.7 |
| AI786089 | Kng | Kininogen | 22.4 | 37.1 | 12.6 |
| AI042655 | Hgfac | Hepatocyte growth factor activator | 4.7 | 9.6 | 8.7 |
| AA608277 | Adora2b | Adenosine A2b receptor | 5.8 | 4.1 | 2.4 |
| AW230369 | Spint1 | Serine protease inhibitor. Kunitz type 1 | 3.0 | 2.7 | 2.3 |
| AA726223 | Adam19 | A disintegrin and metalloproteinase domain 19 (meltrin beta) | 3.2 | 3.3 | 3.1 |
| AW047185 | Thop1 | Thimet oligopeptidase 1 | 4.0 | 2.8 | 4.2 |
| M83649 | Fas | Tumor necrosis factor receptor superfamily. member 6 | –4.2 | –2.6 | –3.6 |
| AI850533 | Bmp6 | Bone morphogenetic protein 6 | –15.5 | –34.8 | –22.8 |
| AA717826 | Dpt | Dermatopontin | –5.0 | –6.7 | –16.6 |
| L48015 | Acvrl1 | Activin A receptor. type II-like 1 | –5.9 | –6.7 | –7.6 |
| L12447 | Igfbp5 | Insulin-like growth factor binding protein 5 | –6.5 | –1.9 | –4.9 |
| X81584 | Igfbp6 | Insulin-like growth factor binding protein 6 | –8.8 | –8.8 | –18.9 |
| AB020886 | Akap12 | A kinase (PRKA) anchor protein (gravin) 12 | –5.8 | –9.0 | –11.9 |
| AI747654 | Cav1 | Caveolin-1. caveolae protein | –4.0 | –5.6 | –6.5 |
| AF080090 | Sema3f | Sema domain. immunoglobulin domain (Ig). short basic domain. secreted. (semaphorin) 3F | –4.9 | –5.4 | –5.6 |
| X70854 | Fbln1 | Fibulin 1 | –3.8 | –3.1 | –10.1 |
| AI853217 | Cdh5 | Cadherin 5 | –7.2 | –9.9 | –10.0 |
| X14432 | Thbd | Thrombomodulin | –16.0 | –27.1 | –55.8 |
| X65493 | Icam2 | Intercellular adhesion molecule 2 | –12.0 | –30.6 | –48.1 |
| X71426 | Tek | Endothelial-specific receptor tyrosine kinase | –12.6 | –16.9 | –26.3 |
| AI843063 | Vwf | Von Willebrand factor homolog | –8.4 | –7.7 | –16.9 |
| U30292 | Col13a1 | Procollagen. type XIII. alpha 1 | –6.2 | –7.3 | –16.7 |
| X79199 | Clec3b | Tetranectin (plasminogen binding protein) | –11.1 | –11.1 | –11.1 |
| U82758 | Cldn5 | Claudin 5 | –9.1 | –17.8 | –45.9 |
| Z38110 | Pmp22 | Peripheral myelin protein | –6.2 | –9.6 | –16.3 |
| X58289 | Ptprb | Protein tyrosine phosphatase. receptor type. B | –14.3 | –21.3 | –40.9 |
| D76440 | Ndn | Necdin | –7.6 | –8.4 | –10.4 |
| Z16406 | Meox2 | Mesenchyme homeobox 2 | –8.6 | –12.6 | –12.6 |
* = A comprehensive list of differentially expressed genes is given in Supplementary Table 1.