Table 3. Results of association study between the four disease activity/severity related measures of RA and two identified susceptible SNPs.

					Discovery Stage			Replication Stage			Combined
Clinical Measurements	Chr	SNP	Position	A1	Beta/OR	STAT	P-value	Beta/OR	STAT	P-value	Beta/OR	STAT	P-value
DAS28*	21	rs1893592	42434957	C	-0.72	-17.46	1.28 × 10-48	-0.63	-17.19	7.70 × 10-54	-0.67	-23.92	1.83 × 10-98
	22	rs909685	39351666	T	0.10	1.66	0.0990	0.02	0.44	0.6621	0.04	1.15	0.2508
CPR level*	21	rs1893592	42434957	C	-8.95	-6.05	4.02 × 10-9	-4.07	-3.96	8.43 × 10-95	-5.8	-6.84	1.48 × 10-11
	22	rs909685	39351666	T	1.85	1.10	0.2729	-0.28	-0.26	0.7943	0.39	0.43	0.6647
Extra-Articular**	21	rs1893592	42434957	C	1.13	0.44	0.6620	1.19	0.81	0.4193	1.16	0.87	0.3822
	22	rs909685	39351666	T	1.16	0.50	0.6177	1.34	1.38	0.1687	1.28	1.45	0.1476
Erosion**	21	rs1893592	42434957	C	0.47	-3.63	0.0003	0.59	-3.57	0.0004	0.55	-4.91	8.95 × 10-7
	22	rs909685	39351666	T	0.90	-0.49	0.6239	1.36	2.05	0.0400	1.19	1.46	0.1433

Chr, Chromosome; A1, minor allele; CRP, C-reactive protein; DAS28, 28-joints disease activity score; OR, odds ratio.

^* linear regression models were fitted.

^** logistic regression models were utilized.