Table 1. Protein levels in circulation and mRNA expression in tissue.

	Protein levels in circulation		mRNA expression in tissue 1		AUC Circulating proteins
						Confidence interval
	p-value	SCCT vs C	P-value	SCCT vs C	AUC	Lower Bound	Upper Bound
NT-3	0,002	Down*	1,11E-02	Down*	0,903	0,805	1,000
TNFB	0,001	Down*	6,64E-05	Up*	0,889	0,786	0,993
CD5	0,008	Down*	4,04E-04	Up*	0,831	0,694	0,968
uPA	0,014	Down*	1,21E-10	Up*	0,825	0,686	0,965
IL-1ra	0,031	Up*	3,77E-05	Down*	0,806	0,670	0,942
Flt3L	0,018	Down*	1,04E-02	Up*	0,803	0,656	0,950
DNER	0,031	Down*	1,08E-05	Down*	0,781	0,631	0,931
CXCL1	0,047	Down*	2,31E-06	Up*	0,770	0,607	0,933
CD6	0,018	Down*	2,02E-07	Up*	0,767	0,615	0,919
CD40	0,047	Down*	4,69E-07	Up*	0,765	0,605	0,924
CDH3	0,014	Down*	1,80E-11	Up*	0,737	0,570	0,904
PECAM-1	0,014	Down*	1,21E-02	Up*	0,731	0,560	0,902
TIE2	0,031	Down*	2,22E-02	Down*	0,712	0,538	0,886
FasL	0,031	Down*	7,72E-03	Up*	0,709	0,538	0,881
FR-alpha	0,047	Down*	3,55E-02	Up*	0,693	0,519	0,867
CD69	0,044	Down*	4,69E-07	Up*	0,676	0,495	0,856
CD244	0,012	Down*	5,33E-01	Down	0,845	0,723	0,967
TWEAK	0,010	Down*	6,71E-01	Down	0,834	0,705	0,962
IL-12B	0,026	Down*	4,23E-01	Down	0,795	0,644	0,946
EGFR	0,008	Down*	2,58E-01	Up	0,756	0,593	0,920
NTRK3	0,016	Down*	2,58E-01	Down	0,731	0,562	0,900
ErbB4/HER4	0,031	Down*	6,71E-01	Down	0,690	0,515	0,864
IL-12	0,047	Down*	6,47E-01	Up	0,676	0,487	0,865

^* Significant differential expression

¹Data from Boldrup et al. 2017 ([26])