Table 1. Physical and biochemical parameters of experimental animals (at day 7 of 5.5 mg/kg ADR injection).
| Parameters | Ctrl (n=5) | iPS-MSCs (n=5) | ADR (n=6) | ADR+iPS-MSCs (n=5) |
|---|---|---|---|---|
| Body weight (g) | ||||
| baseline | 27.1±2.0 | 25.5±2.2 | 25.0±1.0 | 25.4±2.2 |
| day 7 | 27.5±1.1 | 27.6±2.1 | 18.7±1.8a | 21±1.6b |
| Kidney weight (mg) | ||||
| right | 189.4±22.9 | 204.7±24.4 | 146.5±12.3a | 162.5±12.4b |
| left | 178.6±20.3 | 194.1±17.6 | 135.7±11.9a | 149.7±7.5b |
| UACR (ug/mg) | ||||
| baseline | 41.2±6.8 | 46.5±10.1 | 45.3±10.5 | 42.5±7.5 |
| day 7 | 51.9±28.7 | 43.5±8.8 | 1393.0±1594.0 | 197±142.3 |
| BUN (mg/dl) | ||||
| baseline | 21.3±1.0 | 20.9±3.0 | 21.8±1.2 | 21.6±2.0 |
| day 7 | 19.0±1.5 | 18.5±1.3 | 25.1±3.6a | 17.5±1.8b |
| Serum albumin (g/l) | ||||
| baseline | 70.0±4.0 | 67.9±4.4 | 63.8±7.0 | 69.9±5.8 |
| day 7 | 68.5±6.5 | 67.0±4.6 | 26.8±6.2a | 39.9±11.3b |
UACR: urinary albumin-to-creatinine ratio; BUN: blood urea nitrogen.
ap<0.05 versus corresponding Ctrl group
bp<0.05 versus corresponding ADR group