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. Author manuscript; available in PMC: 2017 Dec 18.
Published in final edited form as: Virology. 2016 Dec 27;502:114–122. doi: 10.1016/j.virol.2016.12.024

Table 2.

Clinical signs and symptoms of A(H5N1) virus infection in ferrets.

Virus Clade % Wt lossa Feverb Nasalc Diarrheac Neurod Lethalitye MDTf Virulenceg
Ck/KR/06 2.2 9.4 (2–6) 2.3 (1) 2/3 0/3 0/3 0/3 – Low
EG/2321 2.2.1 20.5 (8) 2.2 (1) 0/3 1/3 0/3 2/3 8.0 High
EG/4935 2.2.1 8.5 (3–8) 2.3 (2) 0/3 1/3 0/3 0/3 – Low
EG/3072 2.2.1 10.5 (4–12) 1.8 (2) 0/3 0/3 0/3 0/3 – Low
BD/5487 2.2.2.1 8.0 (2–5) 2.0 (1–2) 2/3 0/3 0/3 0/3 – Low
BnSw/HK/10 2.3.2.1b 19.0 (6–7) 2.4 (1) 3/3 3/3 1/3 3/3 6.3 High
Dk/VN/672 2.3.2.1b 18.1 (6–7) 2.2 (1) 3/3 1/3 2/3 3/3 6.7 High
Dk/VN/1206 2.3.2.1a 15.1 (4–7) 1.4 (1) 3/3 1/3 0/3 1/3 7.0 Low
Dk/VN/1232 2.3.2.1a 10.4 (8–10) 1.6 (1) 2/3 0/3 0/3 0/3 – Low
Dk/VN/0004 2.3.2.1c 24.9 (7) 2.8 (1) 2/3 3/3 1/3 3/3 7.0 High
Dk/VN/2848 2.3.2.1c 13.9 (3–10) 2.4 (1) 0/3 0/3 0/3 0/3 – Low
a

Percent mean maximum weight loss. Day range p.i. of maximum weight loss in parentheses.

b

Mean maximum fever reported in degrees centigrade. Day range p.i. of maximumtemperature rise over baseline (37.3–39.2 °C) in parentheses.

c

Incidence of nasal discharge or diarrhea through day 14 p.i., reported as number of ferrets with symptoms/total number of ferrets.

d

Number of ferrets which exhibited neurological symptoms/total number of ferrets. All ferrets exhibiting neurological symptoms were humanely euthanized.

e

Number of ferrets required euthanasia due to severe disease through day 14 p.i./total number of ferrets.

f

Mean day of death among all ferrets which required euthanasia due to severe disease through day 14 p.i.

g

Viruses are defined as possessing high virulence when > 50% lethality is observed following infection.