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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Cancer. 2017 Sep 21;124(1):65–73. doi: 10.1002/cncr.30971

Figure 2. Localization of somatic FOXA2 mutations uncovered in uterine carcinosarcomas and in endometrial carcinomas relative to functional domains of the encoded protein.

Figure 2

(a) Location of somatic FOXA2 mutations in endometrial carcinomas (green squares) and in uterine carcinosarcomas (black squares), relative to mapped functional domains of the protein; the A346Gfs*11 variant found in UCS-5, which did not have paired normal DNA available for analysis, is indicated (yellow square) (b) Overlapping nucleotide deletions result in a cluster of somatic frameshift mutations in the C-terminal region of FOXA2. Deleted nucleotides are indicated by dashes; inserted nucleotides are shown in lower case.